526203-37-2Relevant academic research and scientific papers
O-Protecting groups as long-range stereocontrolling elements in the addition of acetylides to 4-substituted quinolines
Guanti, Giuseppe,Perrozzi, Sara,Riva, Renata
, p. 2703 - 2706 (2002)
Addition of magnesium acetylides in the presence of chloroformate esters to racemic differently O-protected 2-(4-quinolyl)propanols and to enantiopure 2-(4-quinolyl)-1,3-dialkoxypropanes, prepared by a chemoenzymatic route, gives almost exclusive regioselective attack at C-2, with stereoselectivities from moderate to good, depending mainly on the bulkiness of the O-protecting group present.
