526203-41-8

Upstream product

• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 526203-40-7 (R)-2-(quinolin-4-yl)-3-(trityloxy)propan-1-ol 
• 526203-37-2 (S)-acetic acid 2-(quinolin-4-yl)-3-(trityloxy)propyl ester 
• 213478-42-3 Acetic acid (S)-3-hydroxy-2-quinolin-4-yl-propyl ester 
• 76-83-5 trityl chloride 

Relevant academic research and scientific papers

O-Protecting groups as long-range stereocontrolling elements in the addition of acetylides to 4-substituted quinolines

Addition of magnesium acetylides in the presence of chloroformate esters to racemic differently O-protected 2-(4-quinolyl)propanols and to enantiopure 2-(4-quinolyl)-1,3-dialkoxypropanes, prepared by a chemoenzymatic route, gives almost exclusive regioselective attack at C-2, with stereoselectivities from moderate to good, depending mainly on the bulkiness of the O-protecting group present.