526216-47-7

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 873000-76-1 (2R,4S)-2-((R)-1-Benzyloxy-propyl)-4-methyl-hexanal 
• 1576-96-1 (E)-2-penten-1-ol 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 35026-81-4 (2S)-methylbuthyl-1-magnesium bromide 
• 506449-74-7 (2S,3R)-2-((S)-2-Methyl-butyl)-pentane-1,3-diol 
• 94424-88-1 (2R,3R)-3-(ethyloxiran-2-yl)methanol 

Relevant academic research and scientific papers

An efficient enantioselective synthesis of the acyl side chain of polyoxypeptins

An enantioselective synthesis of the acyl side-chain 3 of polyoxypeptins 1 and 2 was achieved by the Sharpless AE, with subsequent regioselective opening of the epoxyalcohol using a Grignard reagent in the presence of CuI, and an aldol condensation using Seebach's ester. The method reported has the advantage of a concise route and excellent enantiomeric purity, as well as starting from readily available chemical substrates and the use of inexpensive reagents.