873000-76-1Relevant academic research and scientific papers
An efficient enantioselective synthesis of the acyl side chain of polyoxypeptins
Qin, Dong-Guang,Yao, Zhu-Jun
, p. 571 - 574 (2007/10/03)
An enantioselective synthesis of the acyl side-chain 3 of polyoxypeptins 1 and 2 was achieved by the Sharpless AE, with subsequent regioselective opening of the epoxyalcohol using a Grignard reagent in the presence of CuI, and an aldol condensation using Seebach's ester. The method reported has the advantage of a concise route and excellent enantiomeric purity, as well as starting from readily available chemical substrates and the use of inexpensive reagents.
