526217-25-4

Upstream product

• 526217-50-5 (1S,2S)-2-[(tert-butyloxycarbonyl)amino]-1-methyl-2-phenylethyl benzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 133735-64-5 (1S,2R)-(+)-1-amino-1-phenyl-2-propanol hydrochloride 
• 526217-24-3 tert-butyl (1S,2R)-2-hydroxy-1-phenylpropylcarbamate 

Downstream Products

• 526217-55-0 {(1S,2S)-2-[Bis-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-phenyl-propyl}-carbamic acid tert-butyl ester 
• 526217-56-1 (1S,2S)-1-methyl-2-phenyl-2-(octanoylamino)ethyl bis(2,2,2-trichloroethyl) phosphate 

Relevant academic research and scientific papers

Organoiodine-Catalyzed Enantioselective Intermolecular Oxyamination of Alkenes

Metal-free, catalytic enantioselective intermolecular oxyamination of alkenes is realized by use of organoiodine(I/III) chemistry. The protocol is applicable toward aryl- and alkyl-substituted alkenes with high enantioselectivity and electronically controlled regioselectivity. The oxyaminated products can be easily deprotected in one step to reveal free amino alcohols in high yields without loss of enantioselectivity. A key to our success is the discovery of a virtually unexplored chemical entity, N-(fluorosulfonyl)carbamate, as a bifunctional N,O-nucleophile.

Highly potent inhibitors of TNF-α production. Part II: Metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally f