5263-08-1

Upstream product

• 88589-76-8 4-methyl-8-hydroxylpsoralen 
• 74-88-4 methyl iodide 
• 7790-21-8 potassium metaperiodate 
• 1228691-29-9 4-methyl-7-formylmethyloxy-8-methoxycoumarin 
• 131410-35-0 (6-formyl-8-methoxy-4-methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid ethyl ester 
• 109563-22-6 (6-formyl-8-methoxy-4-methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid 
• 86290-69-9 8-acetyl-4-methylpsoralen 
• 106738-11-8 9-methoxy-5-methyl-7-oxo-7H-furo[3,2-g]chromene-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA

4-Methyl-8-hydroxylpsoralen (MXan) and 4,9-dimethyl-8-hydroxylpsoralen (DMXan) were synthesized in order to clarify the effect of methyl on the antioxidant effectiveness of xanthotoxol (8-hydroxylpsoralen, Xan), which were assessed by bleaching β-carotene

8-Methoxypsoralen-Nucleic Acid Photoreaction. Effect of Methyl Substitution on Pyrone vs. Furan Photoaddition

We have synthesized a series of 8-methoxypsoralens in which methyl and hydrogen are systematically varied at the 4- and 5'-positions.Analysis of the products resulting from the photoaddition of these four psoralens with the nucleic acid poly(dA-dT) reveals that the product distribution depends on the presence or absence of a 4-methyl substituent.Compounds with the 4-methyl group show an overwhelming preference (ca.98percent) for addition to the furan double bond, while compounds without the 4-methyl show a substantial amount (ca.18percent) of addition to the pyrone double bond.

8-Methoxypsoralen derivatives

The invention relates to synthetic processes to produce the known pharmacologically active 8-methoxypsoralen and derivatives thereof. Also disclosed are various novel intermediates utilized in these processes.