52631-32-0

Upstream product

• 124-40-3 dimethyl amine 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 959245-43-3 1,4-dioxa-spiro[4.5]decane-6-carboxylic acid dimethylamide 
• 419567-33-2 3-oxo-hept-6-enoic acid dimethylamide 
• 52773-39-4 4-[2-(Dichloro-dimethylamino-methyl)-cyclohexylidene]-morpholin-4-ium; chloride 
• 670-80-4 4-cyclohexen-1-ylmorpholine 

Downstream Products

• 1351274-49-1 2-hydroxy-2-(3-methoxyphenyl)-N,N-dimethylcyclohexanecarboxamide 
• 1351274-51-5 2-(3-methoxyphenyl)-N,N-dimethylcyclohex-2-enecarboxamide 

Relevant academic research and scientific papers

Fe(III) Complex Compounds For The Treatment And Prophylaxis Of Iron Deficiency Symptoms And Iron Deficiency Anemias

The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.

Chemoselective carbozincation of cyclopropene for C-C bond formation and cleavage in a single operation

The carbozincation of cyclopropene and cleavage of cyclopropylzinc generates carbanion intermediates, which in turn can generate oligomeric complexes in situ through successive carbozincation reactions. The present reaction controls the carbozincation sequence and C-C bond cleavage to give densely functionalized and sterically congested alkylamines in a single operation. A subtle difference in the substituent at the C=N bond induced chemoselective carbozincation of cyclopropene. The tandem carbozincation of cyclopropene, C-C bond cleavage of the cyclopropylzinc intermediate, and allylation of an unactivated hydrazone proceeds in a single operation. The reaction gives sterically congested amines diastereoselectively. Copyright

Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds

A process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds.

PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS

The present invention relates to a process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds.

MODULATORS FOR AMYLOID BETA

The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

Efficient and reusable PdCl2(MeCN)2/CuCl 2/PEG-400 system for cyclization of alkenyl β-keto esters and amides

PEG-400 [poly(ethylene glycol-400)] was found as an effective medium for the PdCl2(MeCN)2-catalyzed hydroalkylation cyclization of alkenyl β-keto esters and amides. In PEG-400, no additives such as Me 3SiCl and Ln(OTf)3 were required for the complete conversion of alkenyl β-keto esters. The results also snowed that CuCl 2 could promote the reaction. In the presence of PdCl 2(MeCN)2, CuCl2, and PEG-400, various alkenyl β-keto esters and amides underwent a selective cyclization reaction to give good to excellent yields of the desired six-membered-ring carbocycles. Furthermore, the PdCl2(MeCN)2/CuCl2/PEG-400 system could be recycled and reused five times without any loss of catalytic activity.

Lanthanide triflate-promoted palladium-catalyzed cyclization of alkenyl β-keto esters and amides

(Matrix presented) Lanthanide triflates were found to promote the palladium-catalyzed cyclization of alkenyl β-keto esters and amides. In the presence of catalytic amounts of PdCl2(MeCN)2 and Ln(OTf)3, various alkenyl β-keto esters and amides underwent regioselective cyclization reactions to give six-, seven-, or eight-membered-ring carbocycles in moderate to excellent yields.