5267-53-8

Basic information

• Product Name: α-Phenyl-1-naphthalinmethanamin-Hydrochlorid
• Synonyms: α-Phenyl-1-naphthalinmethanamin-Hydrochlorid
• CAS NO: 5267-53-8
• Molecular Weight: 269.774
• Mol File: 5267-53-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α-Phenyl-1-naphthalinmethanamin-Hydrochlorid(CAS DataBase Reference)
• NIST Chemistry Reference: α-Phenyl-1-naphthalinmethanamin-Hydrochlorid(5267-53-8)
• EPA Substance Registry System: α-Phenyl-1-naphthalinmethanamin-Hydrochlorid(5267-53-8)

Safety Data

• Hazardous Substances Data: 5267-53-8(Hazardous Substances Data)

Upstream product

• 451503-13-2 (R)-(-)-2-methyl-N-[(1E)-1-naphthalenylmethylene]-2-propanesulfinamide 
• 66-77-3 1-naphthaldehyde 
• 451503-16-5 (R)-2-methyl-N-[(S)-1-naphthalenylphenylmethyl]-2-propanesulfinamide 
• 451503-17-6 (R)-2-methyl-N-[(R)-1-naphthalenylphenylmethyl]-2-propanesulfinamide 
• 108-86-1 bromobenzene 
• 86-53-3 1-Cyanonaphthalene 
• 642-28-4 phenyl(1-naphthyl)methanol 
• 41839-61-6 1-(1-naphthyl)-1-(2-(1-hydroxyphenyl))methylenimine 

Relevant articles and documents

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is the Partner Organisations 2014.

Synthesis of potential inhibitors of squalenepoxidase with conformationanl fixation of the structural elements of Butenafine

The synthesis of the naphthalinemethanamines 6b-h is reported. To obtain products with conformative rigidity, substituents with gradually increased space demand were placed into the α-position. Since the direct reductive amination of the naphthylalkanones 3 with the amines 9 or 10 was only of very limited use the α-substituted naphthalinmethanamines 2 and 4 were synthesized as useful intermediates by various methods and the desired N-substitution pattern of the target compounds was subsequently built up applying - mostly reductive - alkylation methods.