52679-09-1Relevant articles and documents
Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes
Pieroni, Marco,Lilienkampf, Annamaria,Baojie, Wan,Yuehong, Wang,Franzblau, Scott G.,Kozikowski, Alan P.
scheme or table, p. 6287 - 6296 (2010/03/24)
Tuberculosis (TB), mostly caused by Mycobacterium tuberculosis (Mtb), is one of the leading causes of death from infectious disease worldwide. Its coinfection with HIV and the emergence of multidrugresistant TB(MDR-TB) and extensively drug-resistant TB (X
From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters
Mao, Jialin,Yuan, Hai,Wang, Yuehong,Wan, Baojie,Pieroni, Marco,Huang, Qingqing,Van Breemen, Richard B.,Kozikowski, Alan P.,Franzblau, Scott G.
experimental part, p. 6966 - 6978 (2010/08/20)
Both in vitro and in vivo metabolism studies suggested that 5-(2,8-bis(trifluoromethyl)quinolin-4-yloxymethyl)isoxazole-3-carboxylic acid ethyl ester (compound 3) with previously reported antituberculosis activity is rapidly converted to two metabolites 3