84654-29-5

Basic information

• Product Name: ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE
• Synonyms: ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE;5-bromomethylisoxazole-3-carboxylic acid ethyl ester;WGYWHPXMHCTBIS-UHFFFAOYSA-N
• CAS NO: 84654-29-5
• Molecular Formula: C₇H₈BrNO₃
• Molecular Weight: 234.05
• Mol File: 84654-29-5.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE(84654-29-5)
• EPA Substance Registry System: ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE(84654-29-5)

Safety Data

• Hazardous Substances Data: 84654-29-5(Hazardous Substances Data)

Usage

General Description

ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is a chemical compound with the molecular formula C8H9BrN2O3. It is a member of the isoxazole family, which is known for its diverse biological activities. This particular compound is a bromomethyl-substituted ester of isoxazole-3-carboxylic acid, and it is commonly used in organic synthesis and medicinal chemistry. It is also a versatile building block for the preparation of various pharmaceuticals and biologically active compounds. It may also have potential applications in the development of new drugs, agrochemicals, and materials science. Overall, ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is a valuable and versatile chemical building block with potential for significant impact in various fields of science and technology.

Upstream product

• 626-35-7 nitroacetic acid ethyl ester 
• 18719-27-2 5-bromo-pent-2-yne 
• 3405-77-4 5-methylisoxazole 3-carboxylic acid 
• 95080-93-6 ethyl chlorooximidoacetate 
• 106-96-7 propargyl bromide 
• 123770-62-7 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 
• 92274-33-4 chloro-hydroxyimino-acetic acid ethyl ester 
• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 

Downstream Products

• 823219-92-7 5-(2-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-87-0 5-(4-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 1217903-45-1 5-(4-nitro-3-trifluoromethylphenoxymethyl)isoxazole-3-carboxylic acid ethyl ester 
• 1403332-70-6 (S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide 
• 1257629-87-0 C₁₄H₁₃F₃N₂O₄ 
• 1257629-86-9 C₁₅H₁₈N₂O₅ 
• 1257629-80-3 C₁₄H₁₃N₃O₃ 
• 1257629-92-7 C₁₅H₁₅F₃N₂O₃ 
• 1257629-91-6 C₁₅H₁₅F₃N₂O₄ 
• 1257629-79-0 C₁₅H₁₈N₂O₃ 
• 1257629-81-4 C₁₄H₁₆N₂O₄ 
• 1257629-85-8 C₁₃H₁₁F₃N₂O₃ 
• 1257629-84-7 C₁₃H₁₂F₂N₂O₃ 
• 1257629-78-9 C₁₃H₁₂F₂N₂O₃ 

Relevant articles and documents

Solvent-free synthesis of 3,5-isoxazoles via 1,3- dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions

Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al2O3 nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations.

SMALL MOLECULES AND METHODS OF REDUCING INJURIES CAUSED BY RADIATION OR CHEMICALS

A series of small molecule, radioprotective agents based on a compound of the general formula (I): or pharmaceutically acceptable salts thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S, and use of the compounds to protect healthy tissue/organs of subjects to reduce the injuries caused by radiation or chemicals.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.