84654-29-5

Usage

Uses

Used in Organic Synthesis:
ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is used as a building block in organic synthesis for the preparation of various pharmaceuticals and biologically active compounds.
Used in Medicinal Chemistry:
It is utilized as a key intermediate in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Drug Development:
ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is used as a starting material in the synthesis of potential new drugs, with its unique structure offering opportunities for novel therapeutic agents.
Used in Agrochemicals:
ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is also used as a component in the development of agrochemicals, potentially contributing to the creation of new pesticides or other agricultural products.
Used in Materials Science:
ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE is employed in materials science for the development of new materials with specific properties, such as those with enhanced stability or reactivity.

Upstream product

• 106-96-7 propargyl bromide 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 
• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 
• 92274-33-4 chloro-hydroxyimino-acetic acid ethyl ester 
• 123770-62-7 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 
• 626-35-7 nitroacetic acid ethyl ester 
• 18719-27-2 5-bromo-pent-2-yne 
• 3405-77-4 5-methylisoxazole 3-carboxylic acid 
• 95080-93-6 ethyl chlorooximidoacetate 

Downstream Products

• 823219-92-7 5-(2-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-91-6 5-(2,4,6-trimethyl-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-96-1 5-(4-fluoro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-90-5 5-(4-methoxy-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-86-9 5-(3-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-95-0 5-(3-bromo-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-89-2 5-(2-isopropyl-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-94-9 5-(2-bromo-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-88-1 5-(3-methoxy-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-93-8 5-(3,4-dichloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-98-3 5-(4-trifluoromethyl-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-97-2 5-(2-trifluoromethyl-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823220-01-5 5-(3-trifluoromethyl-benzylsulfanylmethyl)-isoxazole-3-carboxylic acid ethyl ester 
• 823219-85-8 5-p-tolylsulfanylmethyl-isoxazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Solvent-free synthesis of 3,5-isoxazoles via 1,3- dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions

Scalable, solvent-free synthesis of 3,5-isoxazoles under ball-milling conditions has been developed. The proposed methodology allows the synthesis of 3,5-isoxazoles in moderate to excellent yields from terminal alkynes and hydroxyimidoyl chlorides, using a recyclable Cu/Al2O3 nanocomposite catalyst. Furthermore, the proposed conditions are reproducible to a 1.0-gram scale without further milling time variations.

SMALL MOLECULES AND METHODS OF REDUCING INJURIES CAUSED BY RADIATION OR CHEMICALS

A series of small molecule, radioprotective agents based on a compound of the general formula (I): or pharmaceutically acceptable salts thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S, and use of the compounds to protect healthy tissue/organs of subjects to reduce the injuries caused by radiation or chemicals.

A Facile Approach to the Synthesis of 3-Acylisoxazole Derivatives with Reusable Solid Acid Catalysts

Nitrile oxides were formed from nitro ketones using silica gel-supported sodium hydrogen sulfate (NaHSO4/SiO2) or Amberlyst 15 as solid acid catalyst, and then the corresponding 3-acylisoxaszoles were obtained by reacting with alkynes via the 1,3-dipolar [3+2] cycloaddition. These heterogeneous catalysts are easily separable from the reaction mixture and reused. This synthetic method provides a facile, efficient, and reusable production of 3-acylisoxazoles.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.

Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3 + 2] cycloaddition of CF3-substituted alkenes and halogenoximes bearing ester, bromo, c

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

INHIBITORS OF PDE6DELTA FOR USE IN THE PREVENTION AND/OR TREATMENT OF EPILEPSY AND/OR NEURODEGENERATIVE DISORDERS

The present provides compounds and methods for preventing and/or treating epilepsy and/or neurodegenerative disorders. More particularly, the invention provides inhibitors of PDE6δ for use in the prevention and/or treatment of neurodegenerative disorders and/or epilepsy.

COMPOUNDS FOR THE TREATMENT OF EPILEPSY, NEURODEGENERATIVE DISORDERS AND OTHER CNS DISORDERS

The present invention relates to a compound of formula (I) or a tautomer thereof, wherein R1, R2, R3, R4 and R5, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of epilepsy and/or neurodegenerative diseases.