52683-81-5

Basic information

• Product Name: L-Proline, 4,4-difluoro- (9CI)
• Synonyms: L-Proline, 4,4-difluoro- (9CI);4,4-difluoroproline;4,4-difluoro-L-Proline;(S)-4,4-Difluoropyrrolidine-2-carboxylic acid;(2S)-4,4-Difluoropyrrolidine-2-carboxylic acid
• CAS NO: 52683-81-5
• Molecular Formula: C₅H₇F₂NO₂
• Molecular Weight: 151.1113864
• Product Categories: GLYCINESCAFFOLD;PYRROLE;CARBOXYLICACID
• Mol File: 52683-81-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 254°Cat760mmHg
• Flash Point: 107.4°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 0.00548mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.40±0.40(Predicted)
• CAS DataBase Reference: L-Proline, 4,4-difluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 4,4-difluoro- (9CI)(52683-81-5)
• EPA Substance Registry System: L-Proline, 4,4-difluoro- (9CI)(52683-81-5)

Safety Data

• Hazardous Substances Data: 52683-81-5(Hazardous Substances Data)

Usage

General Description

L-Proline, 4,4-difluoro- (9CI) is a chemical compound with the molecular formula C5H8F2NO2. It is a derivative of the amino acid L-proline, which plays a crucial role in protein synthesis and has various biological functions in the human body. The addition of two fluorine atoms to the proline molecule alters its chemical properties and potentially enhances its usefulness in pharmaceutical and chemical research. L-Proline, 4,4-difluoro- (9CI) may have applications in drug design and development, as well as in the study of protein structure and function. Further research is needed to fully understand the potential uses and effects of L-Proline, 4,4-difluoro- (9CI) in various fields.

InChI:InChI=1/C5H7F2NO2/c6-5(7)1-3(4(9)10)8-2-5/h3,8H,1-2H2,(H,9,10)

Upstream product

• 148429-57-6 (S)-3,3-Bis-trifluoromethyl-dihydro-pyrrolo[1,2-c]oxazole-1,6-dione 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 203866-17-5 1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate 
• 102195-80-2 (S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 203866-15-3 1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline 
• 156046-01-4 (5S)-7,7-difluoro-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo<3.3.0>octan-4-one 

Downstream Products

• 203866-21-1 (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid 
• 1578153-71-5 6-((S)-2-carboxy-4,4-difluoro-pyrrolidin-1-ylmethyl)-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 1578153-96-4 (R)-6-((S)-2-carboxy-4,4-difluoro-pyrrolidin-1-ylmethyl)-4-(2,4-dichloro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 1612854-24-6 C₁₉H₂₃BrF₂N₄O₅ 
• 1578153-20-4 (R)-6-((S)-2-carboxy-4,4-difluoro-pyrrolidin-1-ylmethyl)-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 1578153-18-0 (S)-6-((S)-2-carboxy-4,4-difluoro-pyrrolidin-1-ylmethyl)-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 1578153-88-4 (R)-6-((S)-2-carboxy-4,4-difluoro-pyrrolidin-1-ylmethyl)-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES

The present invention relates to ethanediamine-heterocycle compounds that are able to act as inhibitors of PRMTs (protein arginine methyltransferases) for treating cancer and other diseases mediated by PRMTs.

PYRROLOTRIAZINE KINASE INHIBITORS

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid

Syntheses for (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives are described starting from (S)-aspartic acid, using hexafluoroacetone as the protecting reagent and DAST as the fluorinating agent.