52693-86-4

Basic information

• Product Name: (E)-1-(3,4-diMethoxybenzylidene)hydrazine
• Synonyms: (E)-1-(3,4-diMethoxybenzylidene)hydrazine
• CAS NO: 52693-86-4
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.20378
• Mol File: 52693-86-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-1-(3,4-diMethoxybenzylidene)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(3,4-diMethoxybenzylidene)hydrazine(52693-86-4)
• EPA Substance Registry System: (E)-1-(3,4-diMethoxybenzylidene)hydrazine(52693-86-4)

Safety Data

• Hazardous Substances Data: 52693-86-4(Hazardous Substances Data)

Usage

General Description

(E)-1-(3,4-diMethoxybenzylidene)hydrazine is a chemical compound with the formula C10H14N2O2. It is a hydrazine derivative that contains a benzylidene group and two methoxy substituents on the benzene ring. (E)-1-(3,4-diMethoxybenzylidene)hydrazine is used in organic synthesis for the preparation of various heterocycles and pharmaceuticals. It can also act as a chelating agent in the coordination chemistry of transition metal ions. Additionally, (E)-1-(3,4-diMethoxybenzylidene)hydrazine has shown potential biological activity, including antifungal and antiproliferative properties, making it a subject of interest in medicinal chemistry research.

Upstream product

• 121-33-5 vanillin 
• 5346-37-2 3,4-Dimethoxybenzaldehyde semicarbazone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 40092-07-7 C₁₄H₂₁N₃O₃ 
• 17745-86-7 3,4-dimethoxybenzaldehyde N-[-(3,4-dimethoxyphenyl)methylidene] hydrazone 
• 1418317-22-2 (E)-1,2-dimethoxy-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 40092-40-8 C₁₃H₁₉N₃O₃ 

Relevant articles and documents

Palladium-catalyzed hydroalkylation of methylenecyclopropanes with simple hydrazones

A palladium-catalyzed hydroalkylation reaction of methylenecyclopropanes via highly selective C-C σ-bond scission was achieved under mild conditions, in which simple hydrazones served as carbanion equivalents. This method featured good functional group compatibility, affording high yields of C-alkylated terminal alkenes.

Nickel-Catalyzed Cross-Coupling of Umpolung Carbonyls and Alkyl Halides

An effective nickel-catalyzed cross-coupling of Umpolung carbonyls and alkyl halides was developed. Complementary to classical alkylation techniques, this reaction utilizes Umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.

Umpolung cross-coupling of polyfluoroarenes with hydrazones: Via activation of C-F bonds

An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp2)-C(sp3) bonds is developed. In this strategy, the C-F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.