52699-46-4Relevant academic research and scientific papers
Characterization of diastereomeric and enantiomeric ephedrines by gas chromatography combined with electron impact mass spectrometry and isobutane chemical ionization mass spectrometry.
Gilbert,Brooks
, p. 226 - 231 (1977)
The diastereomeric hydroxyamines, ephedrine and psi-ephedrine, were well differentiated by gas chromatography of their N-acetyl O-trimethylsilyl derivatives. For the analytical separation of enantiomers, conversion into N-(R)-alpha-phenylbutyryl O-trimethylsilyl derivatives was effective in the cases of ephedrine, psi-ephedrine and nor-psi-ephedrine (but not that of nor-ephedrine, on the two stationary phases used). Electron impact mass spectra showed structurally diagnostic fragmentations, but the two diastereomeric amides from each pair of enantiomers yielded generally similar spectra. Molecular ions were of low abundance, but under chemical ionization conditions (isobutane) abundant protonated molecular ions were produced.
An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
Mocci, Rita,De Luca, Lidia,Delogu, Francesco,Porcheddu, Andrea
supporting information, p. 3135 - 3144 (2016/10/09)
An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).
Mild decarboxylative activation of malonic acid derivatives by 1,1′-carbonyldiimidazole
Lafrance, Danny,Bowles, Paul,Leeman, Kyle,Rafka, Robert
supporting information; experimental part, p. 2322 - 2325 (2011/06/26)
Chemical equations presented. Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N′-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4 (3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Mai,Sbardella,Artico,Ragno,Massa,Novellino,Greco,Lavecchia,Musiu,La Colla,Murgioni,La Colla,Loddo
, p. 2544 - 2554 (2007/10/03)
5-Alkyl-2-(alkylthio)-6-(2,6-difluorobenzyl)-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs 2) have been recently described as a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) active at nan
