52730-46-8Relevant academic research and scientific papers
Optical isomers of 2 (2 ethoxyphenoxymethyl)tetrahydro 1,4 oxazine (viloxazine) and related compounds
Howe,Leigh,Rao,Todd
, p. 1074 - 1076 (1976)
The optical isomers of 2 (2 ethoxyphenoxymethyl)tetrahydro 1,4 oxazine (viloxazine) and 2 (3 methoxyphenoxymethyl)tetrahydro 1,4 oxazine have been prepared and absolute configurations have been assigned. In their action on the central nervous system the S isomers are at least ten times more potent than the R isomers. The intermediate 4 benzyl 2 (p toluenesulfonyloxymethyl) tetrahydro 1,4 oxazine has been resolved. Its isomers provide a convenient starting point for the preparation of optical isomers of viloxazine analogues of known configuration.
Substituted morpholine compounds for the treatment of central nervous system disorders
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Page/Page column 35, (2010/02/14)
This invention relates to compounds of the formulae I wherein R1-R8, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
