52731-18-7Relevant academic research and scientific papers
The Synthesis of Hexahydrooxoepithiopyridinedicarboximides by the Reaction of Thioamides with N-substituted Maleimides
Takido, Toshio,Tamura, Sachiko,Sato, Kenji,Kamijo, Haruo,Nakazawa, Toshikatsu,Hata, Tadashi,Seno, Manabu
, p. 437 - 443 (1998)
The synthesis of hexahydrooxoepithiopyridinedicarboxyimide (5: X2 = N-Ph) by the reaction of thioamides 1 with N-substituted maleimide (2a) was examined. The reaction of primary thioamides, such as thiobenzamide and N-toluthioamide with N-phenylmaleimide gives compounds 5 together with corresponding 4-hydroxy-1,3-thiazoles 4, However, a similar reaction of secondary thioamides, such as N-methylthioacetamide, thiobenzanilide, with N-phenylmaleimide did not provide compounds 5 without addition of acid. The reaction pathway and the configuration of 5 were also investigated.
