52744-21-5

Upstream product

• 1174-72-7 tetraphenoxysilane 
• 1779-48-2 phenylphosphinic acid 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 1150659-80-5 phenyl [(5-hydroxymethylfuran-2-yl)(phenylamino)methyl]phenylphosphinate 
• 1150659-83-8 2,3:5,6-di-O-cyclohexylidene-1-deoxy-1-[phenyloxy(phenyl)phosphoryl]-1-phenylamino-D-mannite 
• 1150659-84-9 1-deoxy-2,3:5,6-di-O-isopropylidene-1-[phenoxy(phenyl)phosphoryl]-1-(2-naphthylamino)-D-mannite 
• 1150659-79-2 phenyl [(2-furyl)(phenylamino)methyl]phenylphosphinate 
• 75754-61-9 ((2R,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-1-hydroxy-4,4-dimethoxy-butyl)-phenyl-phosphinic acid phenyl ester 

Relevant academic research and scientific papers

Silver(I) Promoted the C4-H Bond Phosphonation of 1-Naphthylamine Derivatives with H-Phosphonates

A simple and efficient protocol for silver-promoted direct C-H phosphonation of 1-naphthylamine derivatives with H-phosphonates was described. This reaction proceeded smoothly for 1-naphthylamine derivatives at the C4 site, providing a facile and efficient route to 4-phosphonated 1-naphthylamine derivatives. This phosphonation could tolerate a diverse type of functional groups at the pyridinyl and naphthyl moieties. Further functionalization of the phosphonated product was also explored at the C2 and C8 sites, such as fluoridation, methylation, methoxylation, and amination. In addition, DFT studies of the reaction intermediate showed that the most electrophilic reactive site is at the C4 site in the naphthyl ring.

Metal-Free Electrophilic Phosphination/Cyclization of Alkynes

A metal-free electrophilic phosphination reaction has been developed. Electrophilic phosphorus species generated in situ from secondary phosphine oxides and Tf2O smoothly couple with alkynes possessing pendant nucleophiles to afford the corresponding phosphinated cyclization products in good yield. Preliminary NMR studies show that phosphirenium species may be involved as intermediates of the cyclization reactions.

Orthosilicate-mediated esterification of monosubstituted phosphinic acids

(matrix presented) Monosubstituted phosphinic acids are esterified with orthosilicates in excellent yields. Phosphinylidene-containing acids react selectively under these conditions, while disubstituted phosphinic acids and phosphonic acids remain unchanged. One-pot procedures are also described for the preparation of phosphinate esters from an alcohol. This novel method provides a convenient and general alternative to more commonly employed conditions such as diazomethane or carbodiimide.