52756-36-2

Usage

Uses

Used in Pharmaceutical Industry:
4-tert-butyl-3-chlorobenzenamine is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and pharmaceutical research.
Used in Agrochemical Industry:
In the agrochemical sector, 4-tert-butyl-3-chlorobenzenamine is utilized as a building block for the synthesis of agrochemicals. Its properties make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and productivity.
Used in Specialty Chemicals Industry:
4-tert-butyl-3-chlorobenzenamine is employed as a precursor in the production of specialty chemicals. Its versatility and unique structure make it an essential component in the synthesis of various high-value chemicals used in different applications, such as coatings, adhesives, and polymers.
Used in Dyes and Pigments Industry:
As a precursor in the production of dyes and pigments, 4-tert-butyl-3-chlorobenzenamine plays a crucial role in the development of new colorants for various industries, including textiles, plastics, and printing inks. Its properties contribute to the creation of vibrant and stable colors, enhancing the aesthetic appeal and performance of various products.

Upstream product

• 52756-38-4 1-(tert-butyl)-2-chloro-4-nitrobenzene 
• 6310-21-0 2-(1,1-dimethylethyl)-benzenamine 
• 103392-84-3 2-tert-Butyl-5-nitro-phenylamine 
• 3282-56-2 4-tert-butylnitrobenzene 

Downstream Products

• 34593-73-2 3-chloro-4-(1,1-dimethylethyl)phenol 
• 1452184-10-9 4-tert-butyl-3-chlorobenzene-1-sulfonyl chloride 
• 1452182-86-3 4-tert-butyl-3-chloro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds

A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-1-(4-m

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Drugging large protein pockets is a challenge due to the need for higher molecular weight ligands, which generally possess undesirable physicochemical properties. In this communication, we highlight a strategy leveraging small molecule active site dimers

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR(9) receptor for treating Sjogren's syndrome. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions.

AMIDE COMPOUND

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

Heterocyclic compound

The present invention relates to compound (I) or a salt thereof which has a ROR γ t inhibitory action. wherein each symbol is as defined in the specification.

Oxidative fluorination of N-arylsulfonamides

We report a late stage oxidative nucleophilic fluorination of N-arylsulfonamides, a class of compounds so far not considered as precursors to 4-fluorophenyl sulfonamides. By installing a para-positioned tert-butyl substituent on the aniline, oxidative fluorination takes place regioselectively in the presence of HF·pyridine and PIDA. This methodology has been shown to give good yields for a variety of ortho- and meta-functionalised N-arylsulfonamides and has been adapted for radiofluorination to give 4-[18F]fluorophenyl sulfonamides under carrier added conditions.

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

Substituted N-sulfonylaminobenzyl-2-phenoxyacetamide compounds as VR1 receptor agonists

This invention provides a compound of the formula (I): wherein R1 represents a (C1-C6)alkyl group; R2 represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1-C6) alkyl group or a