52759-08-7 Usage
Description
7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline is a chemical compound characterized by a tetrahydroisoquinoline backbone with methoxy groups at the 7 and 8 positions. It is a natural product derived from various plant sources and has been synthesized for research purposes. 7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline exhibits potential pharmacological activities, such as anti-inflammatory, antioxidant, and neuroprotective effects, making it a promising target for drug development and medicinal chemistry research.
Uses
Used in Pharmaceutical Industry:
7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline is used as a pharmaceutical candidate for its potential therapeutic applications in treating various diseases and conditions. Its anti-inflammatory, antioxidant, and neuroprotective properties contribute to its potential use in the development of drugs for inflammatory disorders, oxidative stress-related conditions, and neurodegenerative diseases.
Used in Medicinal Chemistry Research:
7,8-diMethoxy-1,2,3,4-tetrahydroisoquinoline serves as a valuable compound in medicinal chemistry research, where its structure and functional groups are studied to understand its biological properties and therapeutic potential. Researchers are exploring its interactions with biological targets and evaluating its efficacy in treating specific diseases, which may lead to the discovery of novel drugs and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 52759-08-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,5 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52759-08:
(7*5)+(6*2)+(5*7)+(4*5)+(3*9)+(2*0)+(1*8)=137
137 % 10 = 7
So 52759-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO2/c1-13-10-4-3-8-5-6-12-7-9(8)11(10)14-2/h3-4,12H,5-7H2,1-2H3
52759-08-7Relevant articles and documents
A synthesis of mono- and dimethoxy-1,2,3,4-tetrahydroisoquinolines via Pummerer reaction: Effects of methoxyl groups on intramolecular cyclization
Shinohara, Tatsumi,Takeda, Akira,Toda, Jun,Ueda, Yoko,Kohno, Michiyo,Sano, Takehiro
, p. 918 - 927 (2007/10/03)
A synthesis of 1,2,3,4-tetrahydroisoquinolines (TIQs) (23) with one and two methoxyl groups at various positions of the benzene ring was achieved via the intramolecular cyclization of N-(aryl)methyl-2- (phenylsulfinyl)ethylamines (9) using the Pummerer reaction as a key step. The reaction was carried out by using trifluoroacetic anhydride (TFAA) (method A) or TFAA-BF3 · Et2O (method B). The cyclization to 4-SPhTIQs (11) proceeded effectively when the reaction center at the benzene ring was electronically activated by a methoxyl group. In the reaction of the sulfoxide (9e) having two OMe groups at ortho- and para-positions a different cyclization reaction leading to a benzothiazepine (12) was observed, indicating that the high nucleophilicity of the benzene ring caused the unexpected reaction prior to the cyclization to 4-SPhTIQ (11e). The route starting from methoxylated benzaldehydes (5) was proved to provide an efficient and convenient method of TIQ synthesis which should be complementary to the well known Pictet-Spengler method.
