52763-06-1Relevant academic research and scientific papers
Electrophilic chloro(ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: Facile synthesis of β-chloroethers
Jia, Yimin,Chen, Long,Zhang, Huaibin,Zheng, Ying,Jiang, Zhong-Xing,Yang, Zhigang
, p. 7203 - 7213 (2018/10/24)
A four-component reaction for electrophilic chloro(ω-alkoxy)lation of alkenes has been described. The stable chloro-iodine(iii) reagent and SOCl2 were used as electrophilic and nucleophilic chlorine sources, respectively. This approach provides a straightforward way to synthesize various useful β-chloro ω-chloroalkyl ethers from a wide range of alkenes, including electron-deficient, aromatic and unactivated alkenes. The synthetic applications of this approach were also explored in some useful transformations.
