52767-93-8

Usage

Uses

Used in Pharmaceutical Industry:
N,N-dimethyl-N'-[2-(methylthio)-5-pyrimidinyl]Methanimidamide is used as a potential pharmaceutical agent for its unique molecular structure and functional groups. The presence of sulfur in the molecule, due to the methylthio group, may contribute to its reactivity and interaction with biological systems, making it a candidate for further research and development in drug discovery.
Used in Chemical Research:
In the field of chemical research, N,N-dimethyl-N'-[2-(methylthio)-5-pyrimidinyl]Methanimidamide serves as a subject of study for understanding the effects of its molecular structure on chemical reactivity and behavior. Its specific arrangement of functional groups and the inclusion of sulfur may offer insights into new chemical reactions or interactions with other compounds, potentially leading to the development of novel applications in various industries.
Used in Material Science:
N,N-dimethyl-N'-[2-(methylthio)-5-pyrimidinyl]Methanimidamide may also find applications in material science, where its unique molecular structure could be exploited to create new materials with specific properties. N,N-dimethyl-N'-[2-(methylthio)-5-pyrimidinyl]Methanimidamide's potential reactivity and behavior under various conditions could be harnessed to develop materials with tailored characteristics for use in different applications, such as electronics, coatings, or advanced materials.

Upstream product

• 14527-26-5 2-methylisothiourea sulphate 
• 53114-57-1 S-methylisothiourea hydrochloride 

Downstream Products

• 4874-33-3 2-methylthio-5-hydroxypyrimidine 
• 56622-05-0 N'-(2-methanesulfonyl-pyrimidin-5-yl)-N,N-dimethyl-formamidine 

Relevant academic research and scientific papers

Valuable synthetic building blocks: Useful 2-substituted 5-amino-pyrimidines from a stable precursor

An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vinamidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been use

Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids

Several pyridine- and pyrimidine-carboxylic acids were synthesized as ligand candidates for retinoid nuclear receptors, retinoic acid receptors (RARs) and retinoic X receptors (RXRs). Although the pyridine derivatives, 6-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]pyridine- 3-carboxylic acid (2b) and 6-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]pyridin e-3-carboxylic acid (5b) are more potent than the corresponding benzoic acid-type retinoids, Am80 (2a) and Am580 (5a), the replacement of the benzene ring of Am580 (5a), Am555 (6a), or Am55 (7a) with a pyrimidine ring caused loss of the retinoidal activity both in HL-60 cell differentiation assay and in RAR transactivation assay using COS-1 cells. On the other hand, pyrimidine analogs (PA series, 10 and 11) of potent RXR agonists (retinoid synergists) with a diphenylamine skeleton (DA series, 8 and 9) exhibited potent retinoid synergistic activity in HL-60 cell differentiation assay and activated RXRs. Among the synthesized compounds, 2-[N-n-propyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino] pyrimidine-5-carboxylic acid (PA013, 10e) is most active retinoid synergist in HL-60 assay.