4874-33-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinol, 2-(methylthio)(6CI,7CI,8CI,9CI) is used as a synthetic building block for the development of new pharmaceuticals. Its unique structure and reactivity contribute to the creation of novel drug candidates with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Pyrimidinol, 2-(methylthio)(6CI,7CI,8CI,9CI) serves as a key intermediate in the synthesis of various agrochemicals. Its functional groups allow for the development of compounds with specific pesticidal or herbicidal properties, enhancing crop protection strategies.
Used in Research Applications:
5-Pyrimidinol, 2-(methylthio)(6CI,7CI,8CI,9CI) is utilized in research settings for the exploration of its biological activity. Scientists investigate its potential role in medicinal applications, aiming to uncover new avenues for treatment and therapy development.
Used in Chemical Synthesis:
As a versatile chemical compound, 5-Pyrimidinol, 2-(methylthio)(6CI,7CI,8CI,9CI) is employed in various chemical synthesis processes. Its functional groups facilitate the creation of a wide range of chemical products, contributing to the advancement of the chemical industry.

InChI:InChI=1/C5H6N2OS/c1-9-5-6-2-4(8)3-7-5/h2-3,8H,1H3

Upstream product

• 52767-93-8 2-methylthio-5-dimethylaminomethyleneaminopyrimidine 
• 14001-67-3 5-bromo-2-methylthiopyrimidine 
• 940284-18-4 2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 

Downstream Products

• 6090-37-5 5-fluoro-2-(methylthio)pyrimidine 
• 1581683-77-3 tert-butyl (4-(benzylsulfonyl)-6-fluoro-2-((2-(methylsulfonyl)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate 
• 1581683-76-2 tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate 
• 136240-35-2 C₂₅H₂₆N₂O₅S 
• 136240-29-4 4-Hexyloxy-benzoic acid 2-methylsulfanyl-pyrimidin-5-yl ester 

Relevant academic research and scientific papers

A mild and general method for the synthesis of 2-substituted-5-hydroxypyrimidines

5-Bromopyrimidines are converted to 5-hydroxypyrimidines using a mild synthetic procedure. The method is general and can be applied to compounds containing functional groups which are not compatible with the other reagents previously available for this conversion.

PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS

Novel compounds of structure Formula (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R21, T1, T2, T3 and T4 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.

SELECTIVE ACID HYDROLYSIS OF 2-SUBSTITUTED-5-DIMETHYLAMINOMETHYLENEAMINOPYRIMIDINES TO 5-AMINO- AND 5-HYDROXYPYRIMIDINES

Conditions are described for the selective acid hydrolysis of 2-substituted-5-dimethylaminomethyleneaminopyrimidines in 0.2-2 M sulfuric acid, to give high yields of the corresponding 5-amino- and difficultly accessible 5-hydroxypyrimidines.