527679-33-0Relevant academic research and scientific papers
Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.
Brashear, Karen M,Hunt, Cecilia A,Kucer, Brian T,Duggan, Mark E,Hartman, George D,Rodan, Gideon A,Rodan, Sevgi B,Leu, Chi-Tai,Prueksaritanont, Thomayant,Fernandez-Metzler, Carmen,Barrish, Andrea,Homnick, Carl F,Hutchinson, John H,Coleman, Paul J
, p. 3483 - 3486 (2002)
A series of novel, highly potent alpha(v)beta(3) receptor antagonists with favorable pharmacokinetic profiles has been identified. In this series of antagonists, 2-aryl beta-amino acids function as potent aspartic acid replacements.
