6038-55-7Relevant articles and documents
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target
Nguyen, Corinne,Kasinathan, Ganasan,Leal-Cortijo, Isabel,Musso-Buendia, Alexander,Kaiser, Marcel,Brun, Reto,Ruiz-Pérez, Luis M.,Johansson, Nils G.,González-Pacanowska, Dolores,Gilbert, Ian H.
, p. 5942 - 5954 (2007/10/03)
This paper describes a structure-activity study to identify novel, small-molecule inhibitors of the enzyme deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) from parasitic protozoa. The successful synthesis of a variety of analogues of dUMP is de
Thermal degradation of sugar-modified uridine N-oxides: Olefination, oxazolidination and rearrangements
Bera, Sanjib,Pathak, Tanmaya
, p. 13051 - 13062 (2007/10/03)
The degradation pattern of the N-oxides of various tertiary aminouridines is established. The N-oxide of 3'-deoxy-3'-morpholino- arauridine generated double bonds in the carbohydrate moiety without much selectivity, whereas epimino uridine N-oxides genera
Synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides by reaction of 5′-protected nucleoside 2′,3′-dimesylates with telluride dianion: A general route from cis vicinal diols to olefins
Clive, Derrick L. J.,Wickens, Philip L.,Sgarbi, Paulo W. M.
, p. 7426 - 7437 (2007/10/03)
2′,3′-Dimesylates of 5′-protected nucleosides are converted into the corresponding 2′,3′-didehydro2′,3′-dideoxy compounds by treatment with telluride dianion in the form of the sodium or lithium salt. The method is well-suited to the preparation of unsaturated nucleosides that can be converted into compounds that are believed to be useful in the treatment of AIDS. The deoxygenation is general for vicinal dimesylates that have, or may adopt, a synperiplanar conformation. With straight chain compounds the reaction is stereospecific. In some cases, similar, but slower, deoxygenations can be performed with selenide dianion.
