527758-08-3 Usage
Description
(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid is a complex organic compound characterized by its bicyclic heterocycle structure, specifically a naphthyridinyl group, which is a fusion of a pyridine ring with a benzene ring. (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid also features an acrylic acid side chain with a double bond between the second and third carbon atoms. Its unique molecular structure and functional groups suggest potential pharmaceutical or medicinal applications and may serve as a starting material for the synthesis of other compounds.
Uses
Used in Pharmaceutical Industry:
(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid is used as a potential pharmaceutical compound for its unique molecular structure and functional groups. The presence of the naphthyridinyl group and the acrylic acid side chain may contribute to its interaction with biological targets, making it a candidate for the development of new drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid is used as a starting material for the synthesis of other compounds with potential therapeutic applications. Its structural features may be exploited to design and develop novel molecules with specific biological activities.
Used in Chemical Synthesis:
(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid is used as a key intermediate in the synthesis of various complex organic molecules. Its reactive functional groups and unique structure make it a valuable building block for creating a wide range of chemical products, including those with potential applications in materials science, agrochemistry, and other specialized fields.
Check Digit Verification of cas no
The CAS Registry Mumber 527758-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,7,7,5 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 527758-08:
(8*5)+(7*2)+(6*7)+(5*7)+(4*5)+(3*8)+(2*0)+(1*8)=183
183 % 10 = 3
So 527758-08-3 is a valid CAS Registry Number.
527758-08-3Relevant articles and documents
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
Seefeld, Mark A.,Miller, William H.,Newlander, Kenneth A.,Burgess, Walter J.,DeWolf Jr., Walter E.,Elkins, Patricia A.,Head, Martha S.,Jakas, Dalia R.,Janson, Cheryl A.,Keller, Paul M.,Manley, Peter J.,Moore, Terrance D.,Payne, David J.,Pearson, Stewart,Polizzi, Brian J.,Qiu, Xiayang,Rittenhouse, Stephen F.,Uzinskas, Irene N.,Wallis, Nicola G.,Huffman, William F.
, p. 1627 - 1635 (2003)
Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the development of novel antibacterial agents. Previously we reported the development of FabI inhibitor 4 with narrow spectrum antimicrobial activity and in vivo efficacy against Staphylococcus aureus via intraperitoneal (ip) administration. Through iterative medicinal chemistry aided by X-ray crystal structure analysis, a new series of inhibitors has been developed with greatly increased potency against FabI-containing organisms. Several of these new inhibitors have potent antibacterial activity against multidrug resistant strains of S. aureus, and compound 30 demonstrates exceptional oral (po) in vivo efficacy in a S. aureus infection model in rats. While optimizing FabI inhibitory activity, compounds 29 and 30 were identified as having low micromolar FabK inhibitory activity, thereby increasing the antimicrobial spectrum of these compounds to include the FabK-containing pathogens Streptococcus pneumoniae and Enterococcus faecalis. The results described herein support the hypothesis that bacterial enoyl-ACP reductases are valid targets for antibacterial agents.
