52776-39-3Relevant articles and documents
Catalyzed addition of acid chlorides to alkynes by unmodified nano-powder magnetite: Synthesis of chlorovinyl ketones, furans, and related cyclopentenone derivatives in memory of Professor Robert E. Gawley
Cano, Rafael,Yus, Miguel,Ramón, Diego J.
, p. 7056 - 7065 (2013/07/26)
Inexpensive and commercially available nano-powder magnetite is an excellent catalyst for the addition of acid chlorides to internal and terminal alkynes, yielding the corresponding chlorovinyl ketones in good yields. The process has been applied to the synthesis of 5-chloro-4-arylcyclopent-2-enones, 3-aryl-1H-cyclopenta[a]naphthalen-1-ones, and (E)-3-alkylidene-2,3-dihydro-1H- cyclopenta[a]naphthalen-1-ones, just by changing the nature of the starting acid chloride or the alkyne. All tested processes elapse with an acceptable or excellent regio- and stereo-selectivity. Moreover, the use of the iridium impregnated on magnetite catalyst permits the integration of the chloroacylation process with a second dehydrochlorination-annulation process to yield, in one-pot, 1-aryl-2,4-dialkylfurans in good yields, independently of the nature of the starting reagents, and including the heteroaromatic ones.
Iron-catalyzed synthesis of β-chlorovinyl and α,β-alkynyl ketones from terminal and silylated alkynes with acid chlorides
Gandeepan, Parthasarathy,Parthasarathy, Kanniyappan,Su, Tsu-Hui,Cheng, Chien-Hong
experimental part, p. 457 - 468 (2012/04/05)
A simple efficient method for the iron(III)-catalyzed synthesis of substituted β-chlorovinyl ketones and α,β-alkynyl ketones from terminal and silyl-substituted alkynes with acid chlorides, respectively, is described. This method features easily available
