5278-37-5Relevant academic research and scientific papers
FLUORESCENT DYE AGENT AND CARBOSTYRIL COMPOUND
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Paragraph 0129; 0130; 0135; 0136, (2019/04/03)
PROBLEM TO BE SOLVED: To provide a novel fluorescent dye agent. SOLUTION: A fluorescent dye agent contains a carbostyril compound represented by formula (1) [in the formula (1), R1 is H, a halogen atom, a hydroxyl group, a cyano group, a nitro group or the like; R2 is O; R3 is a halogen atom, a carboxyl group, an ester group, an amide group or the like; R4-R6 and R8 independently represent H, a halogen atom, a nitro group, a cyano group or the like, where mutually adjacent groups of R4-R8 may be bound to form a ring; R7 is H, a substituted or unsubstituted aliphatic group or the like]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2
Syniugin, Anatolii R.,Ostrynska, Olga V.,Chekanov, Maksym O.,Volynets, Galyna P.,Starosyla, Sergiy A.,Bdzhola, Volodymyr G.,Yarmoluk, Sergiy M.
, p. 160 - 169 (2016/12/22)
In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.
CARBOXYLIC ACID ARYL AMIDES
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Page/Page column 19; 20, (2012/07/28)
Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer.
