52780-05-9

Upstream product

• 52779-83-6 [4-(1-bromoethyl)phenyl]-2-thienyl ketone 
• 52841-34-6 p-(1-chloroethyl)phenyl thien-2-yl ketone 
• 52841-35-7 (4-bromomethyl-phenyl)-thiophen-2-yl-methanone 
• 52779-85-8 p-(2-thenoyl)hydratroponitrile 
• 40828-46-4 2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid 
• 52779-57-4 methyl-[4-(thiophene-2-carbonyl)-phenyl]-malonic acid diethyl ester 
• 52779-90-5 4-(thien-2-ylcarbonyl)phenylacetic acid 
• 52780-18-4 [4-(thiophene-2-carbonyl)-phenyl]-acetonitrile 
• 579-49-7 2-(4-fluorobenzoyl)thiophene 
• 52780-20-8 α-methyl-4-(2-thienylcarbonyl)benzeneacetyl chloride 

Relevant academic research and scientific papers

Aroyl-substituted phenylacetic acid derivatives

Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.

Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives

A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.