52841-34-6

Downstream Products

• 52779-85-8 p-(2-thenoyl)hydratroponitrile 
• 57931-92-7 3-(dimethylamino)propyl p-(2-thenoyl)hydratropate oxalate 
• 57931-91-6 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate 
• 52780-02-6 2-(diethylamino)ethyl p-(2-thenoyl)hydratropate hydrochloride 
• 52779-97-2 p-(2-thenoyl)hydratropic acid, sodium salt 
• 40828-46-4 2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid 
• 52780-10-6 2-[4-(thiophene-2-carbonyl)-phenyl]-propionamide 
• 52780-07-1 4'-chloro-4-(2-thenoyl)hydratropanilide 
• 52780-05-9 N-phenyl-2-[4-(thiophene-2-carbonyl)-phenyl]-propionamide 
• 57931-90-5 propyl p-(2-thenoyl)hydratropate 
• 52780-11-7 N-hydroxy-2-[4-(thiophene-2-carbonyl)-phenyl]-propionamide 
• 52779-95-0 ethyl p-(2-thenoyl)hydratropate 
• 52841-36-8 2-[4-(2-thienylcarbonyl)phenyl]propanoic acid methyl ester 
• 52780-20-8 α-methyl-4-(2-thienylcarbonyl)benzeneacetyl chloride 

Relevant academic research and scientific papers

Aroyl-substituted phenylacetic acid derivatives

Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.

Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives

A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.