52780-13-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(thien-2-ylcarbonyl)propionic acid is used as an analgesic and anti-inflammatory agent for managing [application reason] conditions such as arthritis, menstrual cramps, and other moderate to severe pain. Its effectiveness in reducing pain and inflammation makes it a valuable compound in the pharmaceutical industry for treating these conditions.
However, it is essential to exercise caution when using tiaprofenic acid due to its potential side effects, which may include stomach ulcers, bleeding, and kidney problems. Additionally, it can interact with other medications, necessitating careful consideration and consultation with healthcare professionals before use.

InChI:InChI=1/C8H8O3S/c1-5(8(10)11)7(9)6-3-2-4-12-6/h2-5H,1H3,(H,10,11)/t5-/m1/s1

Upstream product

• 40828-46-4 2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 132353-69-6 (S)-2-[4-(2-Thiophen-2-yl-[1,3]dioxolan-2-yl)-phenyl]-propionic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester 
• 52780-20-8 α-methyl-4-(2-thienylcarbonyl)benzeneacetyl chloride 
• 4654-39-1 4-bromophenethanol 
• 132353-68-5 [4-(2-Thiophen-2-yl-[1,3]dioxolan-2-yl)-phenyl]-acetic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester 
• 132353-67-4 [4-(2-Thiophen-2-yl-[1,3]dioxolan-2-yl)-phenyl]-acetic acid 
• 73899-15-7 1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane 
• 52779-90-5 4-(thien-2-ylcarbonyl)phenylacetic acid 

Relevant academic research and scientific papers

Enantioselective potential of polysaccharide-based chiral stationary phases in supercritical fluid chromatography

The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. The chiral selectors immobilized on 2.5?μm silica particles were tris-(3,5-dimethylphenylcarmabate) derivatives of cellulose or amylose. The influence of the polysaccharide backbone, different organic modifiers, and different mobile phase additives on retention and enantioseparation was monitored. Conditions for fast baseline enantioseparation were found for the majority of the compounds. The success rate of baseline and partial enantioseparation with cellulose-based chiral stationary phase was 51.9% and 15.4%, respectively. Using amylose-based chiral stationary phase we obtained 76.9% of baseline enantioseparations and 9.6% of partial enantioseparations of the tested compounds. The best results on cellulose-based chiral stationary phase were achieved particularly with propane-2-ol and a mixture of isopropylamine and trifluoroacetic acid as organic modifier and additive to CO2, respectively. Methanol and basic additive isopropylamine were preferred on amylose-based chiral stationary phase. The complementary enantioselectivity of the cellulose- and amylose-based chiral stationary phases allows separation of the majority of the tested structurally different compounds. Separation systems were found to be directly applicable for analyses of biologically active compounds of interest.

Lipase-silicone biocomposites: Efficient and versatile immobilized biocatalysts

The last few decades have seen an explosion in the application of enzymes to organic chemistry, as these biological catalysts have continued to demonstrate their unique synthetic capabilities. Despite this, a key prerequisite for establishing enzymes as standard reagents in synthetic chemistry, specifically the availability of generic technologies providing inexpensive, robust, and reusable heterogeneous biological catalysts, still remains to be fulfilled. Herein, we describe a novel and highly efficient immobilization methodology for one of the most utilitarian classes of biocatalysts, namely, lipases. The procedure is based upon the adsorption of crude and pure lipases onto poly(hydroxymethylsiloxane), followed by the incorporation of the formed adsorbates into room-temperature vulcanizable silicones, to form biocatalytic composites. This provides hyperactivated catalysts showing activity enhancements of up to 54-fold as compared with the native enzymes, catalytic densities of up to several hundred kilo-units per gram of immobilizate, and high operational activity and stability in aqueous and organic media. The flexibility of silicone polymer chemistry enables the catalytic biocomposites to be prepared with a variety of physicochemistries, and to be fabricated as solid monoliths, sheets of thick films, particulates, and solid foams, thereby allowing the production of tailored catalysts for a variety of applications. The production and properties of a range of lipase- silicone composites are discussed, and the extended performances of selected catalysts are compared with those of the free enzymes and commercial heterogeneous biocatalysts in model synthetic reactions.

(R)- and (S)-3-Hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone, New Chiral Auxiliaries for the Asymmetric Synthesis of α-Arylpropanoic Acids.

Reaction of rac-α-arylpropanoyl chlorides with (R)- and (S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone (R)- and (S)-1, in the presence of triethylamine, under standard esterification conditions, gave (R,R)- and (S,S)-3, respectively, with high diastereoselectivity.Controlled acidic hydrolysis afforded the corresponding (R)- or (S)-α-arylpropanoic acids with high enantioselectivity, the chiral auxiliary being recovered efficiently.

Complex-induced proximity effects in enolate formation. Highly diastereoselective α-methylation of binaphthyl esters of arylacetic acids

Highly diastereoselective methylation of binaphthyl esters of arylacetic acids and its application to the syntheses of antiinflammatory drugs, (S)-suprofen and (S)-naproxen.