52797-54-3

Upstream product

• 19257-96-6 2-(2-Pyridyl)benzothiazolin 
• 716-80-3 2-(2'-pyridyl)benzothiazole 
• 1121-60-4 pyridine-2-carbaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 7040-79-1 2-{[pyridin-2-ylmethylidene]amino}benzenethiol 

Downstream Products

• 259671-63-1 1-chloro-3,4-dicyano-6-[2-(2-pyridylmethylamino)phenylsulfanyl]benzene 
• 177161-41-0 [Zn(SC(C₆H₅)3)(C₅H₄NCH₂NHC₆H₄S)] 
• 53266-16-3 [Zn(C₅H₄NCH₂NHC₆H₄S)2] 
• 177161-38-5 [Zn(OCOC₆H₅)(C₅H₄NCH₂NHC₆H₄S)] 
• 177161-39-6 Zn⁽²⁺⁾*Br^(1-)*C₅H₄NCH₂NHC₆H₄S^(1-) = [ZnBr(C₅H₄NCH₂NHC₆H₄S)] 
• 1357109-08-0 C₁₉H₁₈N₂OSSi 
• 1357109-02-4 C₁₈H₁₅BrN₂SSi 
• 1357109-03-5 C₁₉H₁₅N₃OSSi 
• 1357109-12-6 C₁₈H₁₀ClF₅N₂SSi 
• 1357109-10-4 C₁₉H₁₈N₂SSeSi 
• 1357109-11-5 C₁₉H₁₈N₂SSiTe 
• 1357109-04-6 C₁₉H₁₅N₃S₂Si 
• 1357109-05-7 C₁₈H₁₅N₅SSi 
• 1357109-06-8 C₁₉H₁₅F₃N₂O₃S₂Si 

Relevant academic research and scientific papers

Minimum structural requirements for inhibitors of the zinc finger protein TRAF6

Zinc fingers have rarely been regarded as drug targets. On the contrary, the zinc-binding site of enzymes has often been considered a target of inhibitors. We previously developed a dithiol compound called SN-1 that binds to the zinc finger protein tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppresses downstream nuclear factor-κB (NF-κB) signaling. To determine the minimal structure requirements of TRAF6 inhibitors based on SN-1, NF-κB inhibitory activity and cytotoxicity of its derivatives including new compounds were examined. SN-2, an oxidative type of prodrug of SN-1 with 2-nitrophenylthio groups via disulfide, has the minimum structure for an inhibitor of TRAF6, as seen with cellular experiments. The importance of two side chains with a thiol group was shown with molecular modelling. This study may lead to development of selective TRAF6 inhibitors in the near future.

Modulating In Vitro Photodynamic Activities of Copper(II) Complexes

The photodynamic activities of selected copper(II) complexes [Cu(L1)B]ClO4 (1,2) and [Cu(L2)B]ClO4 (3,4), where L1 = 2-[(pyridin-2-yl)methyleneamino]phenol, L2 = 2-[(pyridin-2-yl)methylenea

Synthesis and structural characterisation of neutral pentacoordinate silicon(iv) complexes with a tridentate dianionic N,N,S chelate ligand

A series of novel neutral pentacoordinate silicon(iv) complexes with SiClSN2C, SiBrSN2C, SiSN3C, SiSON2C, SiS2N2C, SiSeSN2C and SiTeSN2C skeletons (compounds 1-12) was

Synthesis of multidentate ligands via reduction of Schiff base-zinc(II) complex and their use for in situ synthesis of potentially biomimetic Type I copper complexes

In an attempt to simulate the properties of blue copper proteins three low molecular weight and low symmetric solid copper(II) complexes have been synthesized. Ligands with highly ' asymmetric coordination environment have been prepared in two steps. The first step involves synthesis of zinc-coordinated Schiff base of benzothiazolines, which are then subjected to reduction followed by removal of the metal ion from these reduced complexes. The free ligands thus generated are then used for in situ complexation with Cu(II). These complexes exhibit an intense S→Cu(II) charge transfer band at ≈ 600 nm with high extinction values, which is characteristic of Type I copper complexes. The conductivity, magnetic susceptibility and IR studies also support the assigned structures to the complexes.

Zinc complexes of the N,N,S ligand (mercaptophenyl)(picolyl)amine

The zinc complex chemistry of the tridentate thiol ligand N-(2-mercaptophenyl)(2-picolyl)amine (MPPAH) differs considerably from that of the aliphatic analogue N-(2-mercaptoethyl)(2-picolyl)amine reported previously. This is due to the lower basicity and hence bridging tendency of its aromatic thiolate function. With zinc salts of oxo anions the 1:1 complexes (MPPA)ZnX (1a-c: X = ONO2, OAc, OBz) are formed which according to spectroscopic data are monomeric while the halide (MPPA)ZnBr (2) seems to be polymeric. In the absence of coordinating anions the monomeric 2:1 complex (MPPA)2Zn (3) results which according to a crystal structure determination contains tetrahedral zinc coordinated by one MPPA ligand in a tridentate fashion while the other is only monodentate and sulfur-bound. A similar N2S2 coordination can be deduced for the 1:1:1 complex (MPPA)Zn(STrt) (4) resulting from ZnEt2, MPPAH and triphenylmethanethiol. VCH Verlagigesdlschaft mbH, 1996.