52798-24-0

Usage

Chemical structure

A biphenyl derivative with two fluorine atoms at the 2 and 4 positions and a nitro group at the 2' position.

Type of compound

Organic compound

Applications

a. Synthesis of pharmaceutical and agrochemical products
b. Potential use in liquid crystal display technology
c. Building block in organic chemistry for creating complex molecules
d. Potential use as a catalyst in organic reactions

Relevance

Subject of interest in scientific research and development due to its properties and reactivity.

Upstream product

• 144025-03-6 2,4-difluorophenylboronic acid 
• 577-19-5 2-nitrophenyl bromide 
• 2265-93-2 2,4-difluoro-1-iodobenzene 

Downstream Products

• 76838-63-6 1-Benzoyl-3-(2',4'-difluoro-biphenyl-2-yl)-thiourea 

Relevant academic research and scientific papers

NaI/PPh3-Mediated Photochemical Reduction and Amination of Nitroarenes

A mild transition-metal- and photosensitizer-free photoredox system based on the combination of NaI and PPh3 was found to enable highly selective reduction of nitroarenes. This protocol tolerates a broad range of reducible functional groups such as halogen (Cl, Br, and even I), aldehyde, ketone, carboxyl, and cyano. Moreover, the photoredox catalysis with NaI and stoichiometric PPh3 provides also an alternative entry to Cadogan-type reductive amination when o-nitrobiarenes were used.

Visible-light-driven Cadogan reaction

Visible-light-driven photochemical Cadogan-type cyclization has been discovered. The organic D-A type photosensitizer 4CzIPN found to be an efficient mediator to transfer energy from photons to the transient intermediate that breaks the barriers of deoxygenation in Cadogan reaction and enables a mild metal-free access to carbazoles and related heterocycles. DFT calculation results indicate mildly endergonic formation of the intermediate complex of nitrobiarenes and PPh3, which corresponds with experimental findings regarding reaction temperature. The robust synthetic capacity of the photoredox Cadogan reaction systems has been demonstrated by the viable productivity of a broad range of carbazoles and related N-heterocycles with good tolerance of various functionalities.

New 2-aryliminoimidazolidines. II. Synthesis and antihypertensive activity of 2-(biphenylimino)-imidazolidines

For improvement of the duration of action of FR35447 (I), 2-(biphenylimino)imidazolidines (III) were synthesized and their hypotensive activity was tested against conscious normotensive rats. 2-(4'-Fluoro-[1,1'-biphenyl]-2ylimino)imidazolidine (III l) exh