528-93-8

Usage

Uses

Used in Medical Applications:
SILVER SALICYLATE is used as an antibacterial agent for its antimicrobial property, which is beneficial in treating various infections and promoting wound healing.
Used in Anti-inflammatory and Analgesic Applications:
SILVER SALICYLATE is used as an anti-inflammatory and analgesic agent, providing relief from pain and reducing inflammation, making it suitable for conditions such as arthritis and other inflammatory disorders.
Used in Healthcare Products:
SILVER SALICYLATE is used as an ingredient in various healthcare products, such as creams and ointments, for its combined properties of antibacterial, anti-inflammatory, and analgesic effects, which are beneficial for skin conditions and minor injuries.

InChI:InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

Upstream product

• 62-53-3 aniline 
• 69-72-7 salicylic acid 
• 54-21-7 sodium salicylate 
• 50-78-2 aspirin 

Downstream Products

• 133-91-5 3,5-diiodosalicylic acid 
• 20210-97-3 ethane-1,2-diyl bis(2-hydroxybenzoate) 
• 71797-18-7 O²,O³,O⁴-triacetyl-O¹-salicyloyl-β-D-glucopyranuronic acid methyl ester 
• 73960-72-2 methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 
• 82703-91-1 Benzyl-2,3,4-tri-O-benzyl-6-O-(methyl-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-didesoxy-D-glycero-α-D-galacto-2-nonulopyranosylonat)-β-D-galactopyranosid 
• 82703-92-2 methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-salicyoyl-D-galacto-2-nonulopyranoside 
• 82703-90-0 (2S,4S,5R,6R)-5-Acetylamino-4-hydroxy-2-((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethoxy)-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 5094-26-8 2-hydroxybenzoylcholine 
• 88962-61-2 (S)-2-[(S)-2-Benzyloxycarbonylamino-3-((3aR,5R,6R,7S,7aR)-6,7-diacetoxy-5-acetoxymethyl-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-2-yloxy)-propionylamino]-4-methyl-pentanoic acid 2-chloro-ethyl ester 
• 88962-58-7 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-seryl-L-leucin-2-chlorethylester 
• 33019-34-0 2-[(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzoic acid 
• 132608-97-0 Sn(C₆H₅)2(C₅H₅)OOCC₆H₄OH 
• 149095-10-3 di-(μ-salicylato-O,O')-bis(1,5-cyclooctadiene)dirhodium(I) 
• 201741-76-6 BiPh₃[O₂CC₆H₄OH-o]2 

Relevant academic research and scientific papers

Ultrasonic accelerated efficient synthesis of aminobenzochromenes using Ag2Cr2O7 nanoparticles as a reusable heterogeneous catalyst

Ag2Cr2O7 nanoparticles were found to be an exceedingly effective catalyst for the mild and green synthesis of aminobenzochromenes. The reaction was performed under ultrasonic irradiation as an innocuous tool and in water a

Polyethylene glycol derivatization of the non-active ion in active pharmaceutical ingredient ionic liquids enhances transdermal delivery

We report the synthesis of four salts composed of the salicylate anion ([Sal]?) paired with tributylammonium ([HN444]+), choline ([Cho]+), 1-methylpyrrolidinium ([HMPyrr]+), and triethylene glycol monomethyl ether tributylammonium ([mPEG3N444]+) cations. Three of the synthesized salts (room temperature liquids [mPEG3N444][Sal] and [Cho][Sal], and a supercooled liquid [HN444][Sal]) belong to the category of ionic liquids (ILs), and one salt (solid [HMPyrr][Sal]) was a crystalline solid. ILs in their neat form were studied for membrane transport through a silicon membrane, and exhibited higher transport compared to a control experiment with sodium salicylate dissolved in mPEG3OH as solvent, but lower membrane transport compared to salicylic acid dissolved in mPEG3OH. The ‘PEGylated’ IL, [mPEG3N444][Sal], crossed the membrane with an ca. ～2.5-fold faster rate than that of any of the non-PEGylated ILs. This work demonstrates not only that API-ILs can eliminate the use of a solvent vehicle during application and notably transport through a membrane as opposed to a higher melting crystalline salt, but also that the membrane transport can be further enhanced by PEGylation of the counter ions.

A simple sonochemical route for synthesis silver selenide nanoparticles from SeCl4 and silver salicylate

For the first time, silver salicylate marked as [Ag(HSal)] was applied to fabricate silver selenide nanoparticles. This article describes a simple approach based on reaction between silver salicylate as an inorganic precursor, SeCl4, and hydrazine hydrate (N2H4.H 2O) via sonochemical route for the fabrication of silver selenide (Ag2Se) nanoparticles. The effect of preparation parameters such as pH, ultrasonic power, and reaction temperature on the morphology of the final products was investigated. Ag2Se nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray energy dispersive spectroscopy (EDS). Taylor & Francis Group, LLC.

Synthesis and characterization of AgSCN micro/nanostructures by sonochemical method

Silver (I) salicylate complex marked as [Ag(HSal)] was prepared, characterized, and applied to fabricate AgSCN micro/nanostructures. The [Ag(HSal)] complex was synthesized by silver nitrate and sodium salicylate via a simple precipitation route. To obtain AgSCN micro/nanostructures, the [Ag(HSal)] complex and KSCN were mixed with molar ratio of 1:1 in the presence of ultrasound irradiation. Besides, the effect of sonication time and surfactant on the morphology and particle size of the products was investigated. In this work, polyvinyl pyrrolidone was used as surfactant to prepare star-like and flower-like AgSCN microstructures. The products were analyzed by FT-IR, XRD, EDS, SEM, and TEM.

Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB

The already known Ag(I)-Sb(III) compound of the formula {Ag(Ph3Sb)3(NO3)} (1) and two novel mixed metal Ag(I)-Sb(III) metallotherapeutics of the formulae {Ag(Ph3Sb)3(SalH)}(2) and {Ag(Ph3Sb)3(Asp)}(3) (SalH2 = salicylic acid, AspH = aspirin or 2-acetylsalicylic acid and Ph3Sb = triphenyl antimony(III)) have been synthesised and characterised by m.p., vibrational spectroscopy (mid-FT-IR), 13C-,1H-NMR, UV-visible (UV-vis) spectroscopic techniques, high resolution mass spectroscopy (HRMS) and X-ray crystallography. Compounds 1,- 3 were treated with the surfactant cetyltrimethylammonium bromide (CTAB) in order to enhance their solubility and as a consequence their bioactivity. The resulting micelles a-c were characterised with X-ray powder diffraction (XRPD) analysis, X-ray fluorescence (XRF) spectroscopy, Energy-dispersive X-ray spectroscopy (EDX), conductivity, Thermal gravimetry-differential thermal analysis (TG-DTA), and atomic absorption. Compounds 1-3 and the relevant micelles a-c were evaluated for their in vitro cytotoxic activity against human cancer cell lines: MCF-7 (breast, estrogen receptor (ER) positive), MDA-MB-231 (breast, ER negative) and MRC-5 (normal human fetal lung fibroblast cells) with sulforhodamine B (SRB) colorimetric assay. The results show significant increase in the activity of micelles compared to that of the initial compounds. Moreover, micelles exhibited lower activity against normal cells than tumor cells. The binding affinity of a-c towards the calf thymus (CT)-DNA, lipoxygenase (LOX) and glutathione (GSH) was studied by the fluorescent emission light and UV-vis spectroscopy.

Silver chromate and silver dichromate nanostructures: Sonochemical synthesis, characterization, and photocatalytic properties

In this work, Ag2CrO4 and Ag2Cr 2O7 nanostructures have been produced via a sonochemical method using silver salicylate as precursor. Besides silver salicylate, Na 2CrO4 and (NH4)2Cr2O 7 as starting reagents were applied. To investigate the effect of preparation parameters on the morphology and particle size of Ag 2CrO4 and Ag2Cr2O7, sonication time, type of surfactant and its concentration were changed. The as-produced nanostructures were characterized by techniques like powder X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy. The scanning electron micrographs showed that particle-like and rod-like nanostructures of Ag2CrO4 and Ag2Cr 2O7 were produced using different surfactants. To investigate the catalytic properties of Ag2CrO4 nanoparticles, photooxidation of methyl orange (MO) was performed. According to the obtained results, it was found that the methyl orange degradation was about 87.3% after 280 min irradiation of visible light.

Application of a new coordination compound for the preparation of AgI nanoparticles

AgI nanoparticles have been sonochemically synthesized by using silver salicylate, [Ag(HSal)], as silver precursor. To investigate the effects of solvent, surfactant concentration, sonication time and temperature on the morphology of AgI nanostructures, several experiments were carried out. The products were characterized by SEM, TEM, XRD, TGA/DTA, UV-vis, and FT-IR. Based on the experimental findings in this research, it was found that the size of AgI nanoparticles was dramatically dependent on the silver precursor, sonochemical irradiation, and surfactant concentration. Sodium dodecyl sulfate (SDS) was applied as surfactant. When the concentration of SDS was 0.055 mM, very uniform sphere-like AgI nanoparticles with grain size of about 25-30 nm were obtained. These results indicated that the high concentration of SDS could prevent the aggregation between colloidal nanoparticles due to its steric hindrance effect.

Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid

Two new mixed ligand silver(I) complexes of formulae {[Ag(tpp) 3(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)2(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characte

Characterising secondary bonding interactions within triaryl organoantimony(v) and organobismuth(v) complexes

The thermodynamically preferred conformations of the five-co-ordinate trigonal-bipyramidal complexes SbPh3CI21 and BiPh3Cl2 2, determined via van der Waals energy calculations, have been found to be in good agreement with the corresponding correlated propeller arrangements which are observed in the solid state. However, similar calculations upon the corresponding diesters SbPh3(O2CR): 3 and BiPhj(O2CR)2 4 [R = C(OH)Ph2 a or C6H4OH-o b] were at variance with the solid state, thereby indicating the participation of stabilising secondary bonding interactions between the metal centre and the carbonyl oxygen atom of the ester moiety. In accord with current Lewis acid-base bonding models, a strong correlation was found to exist between the pATa of the parent acid and the magnitude of the M ... O=C interaction. The complexes 3a,3b and 4a,4b were prepared in order to probe the effect of strong intramolecular hydrogen bonding upon the ability of ester ligands to stabilise sterically disfavoured conformations via anb donation. Single crystal X-ray analyses of 3a,3b and 4a demonstrate that although significant attenuation of the M ... O=C interaction is achieved via strong intramolecular hydrogen bonding,: sterically disfavoured arrangements predominate in the solid state. The Royal Society of Chemistry 2000.

Vibrational study of the salicylate interaction with metallic ions and surfaces

Infrared and Raman spectroscopy are used in this work to study the metallic complexes of salicylic acid with silver and copper, comparing the interaction between salicylate and the cations (Ag+ and Cu2+) in the metal complexes with the SERS spectra when adsorbed on colloidal metal surfaces of the same metals. The salicylate complexes with the above metals were compared to those of Na+, Fe3+ and Al3+ cations. A different interaction mechanism is deduced for salicylate in the metal complex and when adsorbed on the metal surface.