52803-60-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,4-DICHLORO-BENZYLOXY)-BENZALDEHYDE is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow it to be a key component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(2,4-DICHLORO-BENZYLOXY)-BENZALDEHYDE is also utilized as an intermediate for the synthesis of various agrochemicals. Its properties make it suitable for the development of new pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2-(2,4-DICHLORO-BENZYLOXY)-BENZALDEHYDE has potential applications in the field of organic synthesis due to its unique structure and reactivity. It can be used as a building block in the production of other chemical compounds, contributing to the advancement of organic chemistry.
Used in Medicinal Chemistry:
Furthermore, 2-(2,4-DICHLORO-BENZYLOXY)-BENZALDEHYDE may have uses in medicinal chemistry, where its properties can be harnessed for the development of new therapeutic agents and the improvement of existing ones. Its unique structure and reactivity make it a promising candidate for research and development in this field.

InChI:InChI=1/C14H10Cl2O2/c15-12-6-5-11(13(16)7-12)9-18-14-4-2-1-3-10(14)8-17/h1-8H,9H2

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 90-02-8 salicylaldehyde 
• 20443-99-6 2,4-dichlorobenzyl bromide 
• 1777-82-8 (2,4-dichlorophenyl)methanol 

Downstream Products

• 1430842-27-5 2-((2,4-dichlorobenzyl)oxy)benzaldehyde O-(1-methylpiperidin-3-yl) oxime 
• 1430842-21-9 2-((2,4-dichlorobenzyl)oxy)benzaldehyde O-(1-benzylpyrrolidin-3-yl) oxime 
• 1430842-15-1 2-((2,4-dichlorobenzyl)oxy)benzaldehyde O-(1-isopropylpyrrolidin-3-yl) oxime 
• 1430842-09-3 2-((2,4-dichlorobenzyl)oxy)benzaldehyde O-(1-methylpyrrolidin-3-yl) oxime 
• 1430841-94-3 2-(2,4-dichlorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime 

Relevant academic research and scientific papers

Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type i Protein Arginine Methyltransferases

CARM1 (coactivator-associated arginine methyltransferase 1), which belongs to type I PRMTs (protein arginine methyltransferases), is a potential therapeutic target for treatment of multiple cancers. In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC50 = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC50 = 18 ± 2 to 107 ± 6 nM). As a compound with an ethylenediamino motif, the most potent inhibitor, ZL-28-6, also exhibited potent inhibition against other type I PRMTs. Compared to the type I PRMT inhibitor from our previous work (DCPR049_12), ZL-28-6 showed increased potency against CARM1 and decreased activity against other type I PRMTs. Moreover, ZL-28-6 showed better antiproliferation activities toward a series of solid tumor cells than DCPR049_12, indicating its broad spectrum of anticancer activity. In addition, cellular thermal shift and Western blot assays validated that ZL-28-6 could target CARM1 in cells. Taken together, the inhibitor we identified could serve as a potent probe for studying CARM1's biological functions and shed light on the future design of novel CARM1 inhibitors with stronger activities and selectivities.

PRMTI Type methyltransferase inhibition active compound as well as preparation and application thereof

The invention relates to a compound with PRMT I-type methyltransferase inhibition activity and preparation and application thereof, wherein the compound has the structure shown I. The compound of the formula I has a good inhibition effect on PRMT I-type m

Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles

Compounds of the formula STR1 wherein Z is a direct bond or alkylene of 1 - 3 carbon atoms which is unsubstituted or substituted on the carbon atom alpha to the phenyl group by alkyl or unsubstituted or substituted phenyl, R2 and R3 singly are H, alkyl, alkoxy, alkylmercapto, halo, nitro or, collectively, C4 H4, and R4 is alkenyl, alkinyl, unsubstituted or substituted phenyl or phenylalkyl, or, when Z is substituted methylene, also alkyl, are useful in combating Germatophyte infections, especially Trichophyton rubrum and mentagrophytes, and yeast infections, especially Candida albicans, as well as bacterial and fungal infections.