52803-75-5

Basic information

• Product Name: 2-(benzyloxy)-5-chlorobenzoic acid
• Synonyms: 2-(benzyloxy)-5-chlorobenzoic acid;5-chloro-2-(phenylmethoxy)benzoic acid;ST5449595
• CAS NO: 52803-75-5
• Molecular Formula: C₁₄H₁₁ClO₃
• Molecular Weight: 262.68834
• Mol File: 52803-75-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(benzyloxy)-5-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-5-chlorobenzoic acid(52803-75-5)
• EPA Substance Registry System: 2-(benzyloxy)-5-chlorobenzoic acid(52803-75-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 52803-75-5(Hazardous Substances Data)

Usage

General Description

2-(benzyloxy)-5-chlorobenzoic acid is a chemical compound with the molecular formula C14H11ClO3. It is a derivative of benzoic acid and contains a benzene ring with a chloro-substituted carboxylic acid group and a benzyloxy group attached to it. 2-(benzyloxy)-5-chlorobenzoic acid is commonly used in organic synthesis and pharmaceutical research due to its ability to act as a precursor in the formation of various pharmaceutical drugs and agrochemicals. It also has potential applications in the field of materials science and as a building block for the synthesis of various organic compounds.

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 103620-87-7 methyl 5-chloro-2-(phenylmethoxy)benzoate 
• 110-01-0 thiophene 

Downstream Products

• 1198420-12-0 ethyl {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1198420-10-8 ethyl {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1285516-40-6 methyl {3-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 896658-67-6 2-(benzyloxy)-5-chloro-N-(pyridin-3-yl)benzamide 
• 1198420-13-1 {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid 
• 1198420-11-9 {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel N-substituted benzamides as anti-migration agents for treatment of osteosarcoma

A novel series of novel N-substituted (indole or indazole) benzamides were synthesized, and their anti-tumor properties were evaluated. The majority of tested compounds possessed moderate cytotoxicity, but inspiringly, we verified that active compound 5d presents an astonishing advantage by inhibiting the adhesion, migration, and invasion of osteosarcoma (OS) cells in vitro. Mechanistically, we confirmed 5d inhibited the migration ability of OS cells via the expression of genes related to adhesion, migration, and invasion. This effects of 5d suggest that it can be used as a potential chemotherapeutic drug to some aggressive and/or metastatic cancers, as well as in combination with other clinical anti-cancer drugs. In turn, this could enhance the therapeutic effect or reduce the risk of cell migration.

Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors

Leucine-rich repeat kinase 2 (LRRK2) has been suggested as a potential therapeutic target for Parkinson's disease. Herein we report the discovery of 5-substituent-N-arylbenzamide derivatives as novel LRRK2 inhibitors. Extensive SAR study led to the discovery of compounds 8e, which demonstrated potent LRRK2 inhibition activity, high selectivity across the kinome, good brain exposure, and high oral bioavailability.

NOVEL EP4 RECEPTOR AGONIST COMPOUNDS

A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.