52803-75-5

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(benzyloxy)-5-chlorobenzoic acid is utilized as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows for the creation of new drug candidates with potential therapeutic applications, contributing to the advancement of medicine.
Used in Agrochemical Production:
In the agrochemical industry, 2-(benzyloxy)-5-chlorobenzoic acid is employed as a precursor for the development of new pesticides and other agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural settings, supporting crop protection and yield improvement.
Used in Materials Science:
2-(benzyloxy)-5-chlorobenzoic acid is applied as a component in the field of materials science, where it can be used to develop new materials with specific properties. Its structural features make it a valuable building block for creating innovative materials with applications in various industries.
Used in Organic Synthesis:
As a fundamental building block in organic synthesis, 2-(benzyloxy)-5-chlorobenzoic acid is used to construct a wide array of organic compounds. Its versatility in chemical reactions enables the synthesis of complex molecules for use in various chemical and industrial applications.

Upstream product

• 110-01-0 thiophene 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 100-44-7 benzyl chloride 
• 103620-87-7 methyl 5-chloro-2-(phenylmethoxy)benzoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 41220-63-7 2-benzyloxy-5-chlorobenzoic acid chloride 
• 1198420-12-0 ethyl {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1198420-10-8 ethyl {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate 
• 1469996-80-2 5-chloro-2-hydroxy-N-[(2S)-1-oxo-1-[[4-(trifluoromethyl)phenyl]amino]propan-2-yl]benzamide 
• 1469996-61-9 (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]propanoic acid 
• 1469996-54-0 tert-butyl (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]propanoate 
• 1469996-55-1 methyl (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-phenylpropanoate 
• 1469996-56-2 methyl (2R)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-phenylpropanoate 
• 1469996-57-3 methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3,3-dimethyl]butanoate 
• 1469996-58-4 methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate 
• 1469996-59-5 methyl (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]propanoate 
• 896658-67-6 2-(benzyloxy)-5-chloro-N-(pyridin-3-yl)benzamide 
• 1198420-13-1 {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid 
• 1198420-11-9 {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel N-substituted benzamides as anti-migration agents for treatment of osteosarcoma

A novel series of novel N-substituted (indole or indazole) benzamides were synthesized, and their anti-tumor properties were evaluated. The majority of tested compounds possessed moderate cytotoxicity, but inspiringly, we verified that active compound 5d presents an astonishing advantage by inhibiting the adhesion, migration, and invasion of osteosarcoma (OS) cells in vitro. Mechanistically, we confirmed 5d inhibited the migration ability of OS cells via the expression of genes related to adhesion, migration, and invasion. This effects of 5d suggest that it can be used as a potential chemotherapeutic drug to some aggressive and/or metastatic cancers, as well as in combination with other clinical anti-cancer drugs. In turn, this could enhance the therapeutic effect or reduce the risk of cell migration.

Compound C18, preparation method thereof and application of the compound C18 in preparation of anti-lung cancer drugs

The invention discloses a small molecular compound C18 and application thereof in preparation of anti-lung cancer drugs. The structural formula of the C18 is shown in the specification. Experimental results show that C18 can inhibit proliferation and clon

Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors

Leucine-rich repeat kinase 2 (LRRK2) has been suggested as a potential therapeutic target for Parkinson's disease. Herein we report the discovery of 5-substituent-N-arylbenzamide derivatives as novel LRRK2 inhibitors. Extensive SAR study led to the discovery of compounds 8e, which demonstrated potent LRRK2 inhibition activity, high selectivity across the kinome, good brain exposure, and high oral bioavailability.

NOVEL COMPOUNDS

The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.

NOVEL EP4 RECEPTOR AGONIST COMPOUNDS

A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

Benzamide derivatives

Benzamide derivatives of the formula:- STR1 wherein R1 represents a fluorine, chlorine or bromine atom, or an alkyl, alkoxy, alkylthio, alkylsulphonyl, alkanoylamino, alkylamino or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), an alkanoyl, alkoxycarbonyl, alkoxycarbonylamino or alkylcarbamoyl group containing from 2 to 6 carbon atoms, or a hydroxy, formyl, nitro, trifluoromethyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl or aroyl group, and n represents an integer 1, 2 or 3, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.