52804-37-2

Upstream product

• 6793-92-6 p-benzyloxyphenylbromide 
• 19066-26-3 2-(4-methoxyphenyl)(tricyclo[3.3.1.1^3,7]decane) 
• 76481-43-1 2-(4-methoxyphenyl)(tricyclo[3.3.1.1^3,7]decanol) 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 700-58-3 2-Adamantanone 
• 101-84-8 diphenylether 
• 7314-85-4 2-adamantyl bromide 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity

The synthesis and pharmacological evaluation of C1-substituted adamantane hydrazones, their C2-substituted isomers, and C1-substituted adamantane furanoic carboxamides is described. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity. The most active adduct with the best selectivity in this study was found to be the phenylacetoxy hydrazone 1 b (2-[4-(tricyclo[3.3.1.13,7]dec-1-yl)phenyl]-N′-[(5-nitrofuran-2-yl)methylene]acetohydrazide; EC50=11±0.9 nm, SITb=770).

Theory and Practice of the Preparation of Adamantylarenes

Abstract: The adamantylation of diphenyl oxide and phenol with 1-chloro(bromo)adamantanes in a liquid phase has been studied. The reaction has been performed under kinetic control and under the conditions of reaching chemical equilibrium using the following catalysts: Amberlyst 36 Dry, in situ HBr, and AlCl3. The kinetics of isomerization of (1-adamantyl)- and (2-adamantyl)diphenyl oxides has been studied at 333 and 417 K in the presence of AlCl3 and Amberlyst 36 Dry, respectively. The equilibrium of the positional and structural “bridge–bridgehead” isomerization has been studied in the range of 333–523 K. It has been found that high selectivity of the adamantylation of diphenyl oxide or phenol can be achieved in the case of the use of sulfonated cation-exchange resins as a catalyst. In the presence of aluminum halides or HBr, the reaction mixture has been represented by all the possible isomers and adamantane.

Non-catalyzed C-alkylation of phenols with cyclic secondary alkyl bromides

C-Alkylations of phenol with 1-chloro and 1-bromoadamantane, 2-bromoadamantane, cyclohexyl bromide and exo-2-bromonorbornane, and C-alkylations of para-substituted phenol derivatives with 2-bromoadamantane are described.

New aliphatically substituted aryl-chalcogeno-hydrocarbon derivatives

Compounds of the formula I wherein R1 is adamantyl, Ph is phenylene which is optionally substituted by amino, nitro, lower alkyl, lower alkoxy, halogen or trifluoromethyl, X is oxy or thio, alk is alkylene with 1 to 20 C atoms or alkenylene with 2 to 20 C atoms and R2 is free, esterfied or amidised carboxyl, sulpho or sulphonamido and therapeutically acceptable salts thereof are useful as anti-allergic and hypolipidaemic agents.