52805-90-0

Upstream product

• 118-72-9 2,6-dimethylbenzene-1-thiol 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 2905-17-1 bis(2,6-dimethylphenyl)disulfide 
• 576-22-7 2-Bromo-m-xylene 
• 608-28-6 2,6-dimethyliodobenzene 
• 34878-61-0 sodium 2,6-dimethylphenylthiolate 

Downstream Products

• 112399-10-7 bis<2,6-bis(bromomethyl)-phenyl>sulfide 
• 66713-33-5 2,6-Xylyl 2,5-xylenethiosulfonate 
• 66713-32-4 2,6-Xylyl 2,6-xylenethiosulfinate 
• 66713-29-9 2-Hydroxysulfanyl-1,3-dimethyl-benzene 
• 112399-11-8 bis<2,6-bis(bromomethyl)phenyl> sulfoxide 
• 66713-28-8 tert-Butyl 2,6-xylyl sulfoxide 
• 115231-24-8 Bis-(2,6-dimethyl-phenyl)-sulfon 

Relevant academic research and scientific papers

Dechalcogenization of Aryl Dichalcogenides to Synthesize Aryl Chalcogenides via Copper Catalysis

An application for dechalcogenization of aryl dichalcogenides via copper catalysis to synthesize aryl chalcogenides is disclosed. This approach is highlighted by the practical conditions, broad substrate scope, and good functional group tolerance with several sensitive groups such as aldehyde, ketone, ester, amide, cyanide, alkene, nitro, and methylsulfonyl. Furthermore, the robustness of this methodology is depicted by the late-stage modification of estrone and synthesis of vortioxetine. Remarkably, synthesis of more challenging organic materials with large ring tension under milder conditions and synthesis of some halogen contained diaryl sulfides which could not be synthesized using metal-catalyzed coupling reactions of aryl halogen are successfully accomplished with this protocol.

Synthesis method of thioether compounds

The invention discloses a synthesis method of thioether compounds. The method comprises steps as follows: phosphorus trichloride and a solvent with uniformly distributed sulfoxide compounds are mixeduniformly, after mixing, the mixture is subjected to a reaction at the temperature of 20-25 DEG C for 0.5-6 h, and the thioether compounds are obtained, wherein the solvent is acetonitrile. Compared with the prior art, the synthesis method has the advantages that raw materials are cheap and easy to obtain, a reducer is cheap and easy to obtain and store, and a series of thioether compounds can beobtained.

Deoxygenation of sulphoxides to sulphides with trichlorophosphane

An efficient route to deoxygenation of sulphoxides to sulphides with PCl3 under mild reaction condition was developed. PCl3 was used as a reducing agent for the first time to convert sulphoxides to sulphides. The mild conditions, use of cheap and readily available reagent, and broad substrate scope render it a useful strategy for preparing sulphides.

Carbon-sulfur bond formation catalyzed by [Pd(IPr*OMe) (cin)Cl] (cin = cinnamyl)

The newly prepared complex [Pd(IPr*OMe)(cin)(Cl)] provides high catalytic activity for carbon-sulfur cross-coupling reactions. Nonactivated and deactivated aryl halides were successfully coupled with a large variety of aryl- and alkylthiols using this well-defined palladium N-heterocyclic carbene (NHC) complex.

Potassium isopropoxide: For sulfination it is the only base you need!

PEPPSI max: KOiPr has been identified as the key ingredient for Pd-catalyzed sulfination (see scheme). Potassium is essential to keep the thiol concentration low, and isopropoxide is necessary for precatalyst activation and to break up Pd-sufide-based resting states. Together with the reactive Pd-PEPPSI-IPentCl o-picoline catalyst, this system couples profoundly deactivated partners at RT that other catalysts cannot accomplish in refluxing toluene. Copyright

Carbon-sulfur bond formation of challenging substrates at low temperature by using Pd-PEPPSI-IPent

Aryl thiols made cool and quick: The coupling of alkyl, aryl, and silyl thiols to hindered, deactivated aryl bromides and chlorides has been achieved under the most mild temperatures yet reported (i.e., room temperature to 40°C). The bulk afforded by the di-2,6-(3-propylphenyl)imidazolium-derived Pd-PEPPSI-IPent catalyst is believed to actively promote the critical reductive elimination step of the catalytic cycle, thereby eliminating the formation of poisonous off-cycle dimeric resting states that have plagued Pd-catalyzed sulfination reactions.