52833-03-1

Upstream product

• 3731-53-1 4-(aminomethyl)pyridine 
• 30720-05-9 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 30720-04-8 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 59060-16-1 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Downstream Products

• 106447-86-3 4-chloro-5-(4-chlorobenzoyl)-1-ethyl-1H-pyrazolo[3,4-b]pyridine 
• 106811-23-8 (4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2-methoxy-phenyl)-methanone 
• 106811-25-0 4-Chloro-1-ethyl-5-(4-methoxybenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 106811-21-6 4-Chloro-1-ethyl-5-(4-methylbenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 106811-18-1 4-Chloro-5-(3-chlorobenzoyl)-1-ethyl-1H-pyrazolo[3,4-b]pyridine 
• 106811-19-2 4-Chloro-1-ethyl-5-(2-methylbenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 106811-24-9 4-chloro-1-ethyl-5-(3-methoxybenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 106811-16-9 4-Chloro-1-ethyl-5-(3-fluorobenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 39973-71-2 5-benzoyl-4-chloro-1-ethyl-1H-pyrazolo<3,4-b>pyridine 
• 675112-52-4 4-chloro-1-ethyl-N-{[4-(methyloxy)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 71005-94-2 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 865713-88-8 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 675111-72-5 4-chloro-1-ethyl-N-(phenylmethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 39974-80-6 5-benzoyl-1-ethyl-4-hydroxy-1H-pyrazolo<3,4-b>pyridine 

Relevant academic research and scientific papers

PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: formula (I) wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or -CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, c

PYRAZOLO[3,4-B]PYRIDINE COMPOUND, AND ITS USE AS A PDE4 INHIBITOR

The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carb oxamide, which is the compound of formula (I), or a salt thereof. The invention also provides the use of said compound or a pharmaceutically acceptable salt thereof as an inhibitor of phosphodiesterase type IV (PDE4), for example in the treatment and/or prophylaxis of an inflammatory and/or allergic disease, cognitive impairment or depression in a mammal. In particular, the invention provides the use of the compound or pharmaceutically acceptable salt in the treatment and/or prophylaxis of atopic dermatitis in a mammal, for example by external topical administration to the mammal such as a human. Pharmaceutical compositions containing said compound or salt, in particular suitable for external topical administration, are also provided.

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

Fused pyridine inhibitors of cGMP phosphodiesterase

Compounds of the formulas are useful as inhibitors of cGMP PDE, especially type V.

Amino derivatives of pyrazolopyridine carboxamides

4-Amino derivatives of pyrazolo[3,4-b]pyridine-5-carboxamides having the formula SPC1 Are disclosed. The novel compounds are useful as ataractic, analgesic, and hypotensive agents.