52833-03-1

Basic information

• Product Name: 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride
• Synonyms: 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride
• CAS NO: 52833-03-1
• Molecular Formula: C₉H₇Cl₂N₃O
• Molecular Weight: 244.07738
• Mol File: 52833-03-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(52833-03-1)
• EPA Substance Registry System: 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride(52833-03-1)

Safety Data

• Hazardous Substances Data: 52833-03-1(Hazardous Substances Data)

Upstream product

• 59060-16-1 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 30720-04-8 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 3731-53-1 4-(aminomethyl)pyridine 
• 30720-05-9 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Downstream Products

• 106447-86-3 4-chloro-5-(4-chlorobenzoyl)-1-ethyl-1H-pyrazolo[3,4-b]pyridine 
• 106811-23-8 (4-Chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2-methoxy-phenyl)-methanone 
• 106811-25-0 4-Chloro-1-ethyl-5-(4-methoxybenzoyl)-1H-pyrazolo[3,4-b]pyridine 
• 675112-52-4 4-chloro-1-ethyl-N-{[4-(methyloxy)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 675111-72-5 4-chloro-1-ethyl-N-(phenylmethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 71005-94-2 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 865713-88-8 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 39974-80-6 5-benzoyl-1-ethyl-4-hydroxy-1H-pyrazolo<3,4-b>pyridine 
• 118231-39-3 5-benzoyl-1-ethyl-4-hydroxy-1H-pyrazolo<3,4-b>pyridine oxime 
• 118231-40-6 5-benzoyl-1-ethyl-4-hydroxy-1H-pyrazolo<3,4-b>pyridine oxime 
• 106811-13-6 6-ethyl-3-(2-methoxyphenyl)-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridine 
• 106447-66-9 5-benzoyl-1-ethyl-4-<<(isopropylidene)amino>oxy>-1H-pyrazolo<3,4-b>pyridine 
• 106811-15-8 6-ethyl-3-(4-methoxyphenyl)-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridine 
• 106811-14-7 6-ethyl-3-(3-methoxyphenyl)-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridine 

Relevant articles and documents

PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: formula (I) wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or -CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, c

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

Amino derivatives of pyrazolopyridine carboxamides

4-Amino derivatives of pyrazolo[3,4-b]pyridine-5-carboxamides having the formula SPC1 Are disclosed. The novel compounds are useful as ataractic, analgesic, and hypotensive agents.