52837-54-4

Usage

Classification

Oxazolidine (a type of cyclic organic compound)

Appearance

Colorless liquid with a mild odor

Solubility

Soluble in water and many organic solvents

Uses

+ Stabilizer and corrosion inhibitor in industrial processes (e.g. metalworking fluids and lubricants)
+ Chemical intermediate in the production of pharmaceuticals, agricultural chemicals, and other specialty chemicals
+ Precursor in the synthesis of polymers and other organic compounds

InChI:InChI=1/C6H13NO/c1-5-4-7-6(2,3)8-5/h5,7H,4H2,1-3H3

Upstream product

• 3156-73-8 2-hydroxy-1-nitropropane 
• 78-96-6 3-amino-2-propanol 
• 67-64-1 acetone 

Downstream Products

• 52836-31-4 R-29148 

Relevant academic research and scientific papers

One-pot Synthesis, Crystal structure, and Bioactivity of N-Phenoxyacetyl-2,4,5-trisubstituted-1,3-oxazolidines

N-phenoxyacetyl-1,3-oxazolidine derivatives were synthesized by the cyclization and acylation with β-amino alcohol, ketone, and phenoxyacetyl chloride as the starting materials. All compounds were characterized by IR, 1H NMR, 13C NMR, ESI-MS, and elemental analysis. The configuration of 4a was determined by X-ray crystallography. The preliminary biological tests showed that all products could protect soybean against injury caused by 2,4-D butylate to some extent.

Design, synthesis and evaluation of novel trichloromethyl dichlorophenyl triazole derivatives as potential safener

The dominance of safener can unite with herbicides acquiring the efficient protection of crop and qualifying control of weeds in agricultural fields. In order to solve the crop toxicity problem and exploit the novel potential safener for fenoxaprop-P-ethyl herbicide, a series of trichloromethyl dichlorobenzene triazole derivatives were designed and synthesized by the principle of active subunit combination. A total of 21 novel substituted trichloromethyl dichlorobenzene triazole compounds were synthesized by substituted aminophenol and amino alcohol derivatives as the starting materials, using cyclization and acylation. All the compounds were unambiguously characterized by IR,1H-NMR,13C-NMR, and HRMS. A greenhouse bioassay indicated that most of the title compounds could protect wheat from injury caused by fenoxaprop-P-ethyl at varying degrees, in which compound 5o exhibited excellent safener activity at a concentration of 10 μmol/L and was superior to the commercialized compound fenchlorazole. A structure–activity relationship for the novel compounds was determined, which demonstrated that those compounds containing benzoxazine groups showed better activity than that of oxazole-substituted compounds. Introducing a benzoxazine fragment and electron-donating group to specific positions could improve or maintain the safener activity for wheat against attack by the herbicide fenoxaprop-P-ethyl. A molecular docking model suggested that a potential mechanism between 5o and fenoxaprop-P-ethyl is associated with the detoxication of the herbicide. Results from the present work revealed that compound 5o exhibited good crop safener activities toward wheat and could be a promising candidate structure for further research on wheat protection.

Preparation of 3-dihaloacetyl oxazolidines

The disclosure herein relates to a new process for the preparation of 3-dihaloacetyl (un)substituted oxazolidine compounds by the catalytic hydrogenation of nitroalcohols with aldehydes or ketones followed by reaction with a dihaloacetyl halide.

Reductive Alkylation of β-Alkanolamines with Carbonyl Compounds and Sodium Borohydride

A synthesis of secondary alkylalkanolamines from primary alkanolamines in a rapid process in which overalkylation is virtually suppressed is described.The procedure combines the ease of formation of oxazolidines from alkanolamines with aldehydes or ketones in absolute ethanol and the lability of the newly formed C-O bond toward sodium borohydrode.The entire process is carried out in 15-35 min depending on the carbonyl substrate.