52838-99-0Relevant academic research and scientific papers
Synthesis of 3-phenylindoline-2-carboxamides as semi-rigid phenylalanine mimetics
Collot, Valerie,Schmitt, Martine,Marwah, Ashok K.,Norberg, Bernadette,Bourguignon, Jean-Jacques
, p. 8033 - 8036 (1997)
Regioselective catalytic hydrogenation of N-acyl 3-phenylindole-2-carboxylates is the key step for tile preparation of cis and trans ndoline-2-carboxamides which can be considered as phenylalanine semi-rigid derivatives.
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
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Page/Page column 34, (2008/06/13)
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.
Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines
Collot, Valerie,Schmitt, Martine,Marwah, Padma,Bourguignon, Jean-Jacques
, p. 2823 - 2847 (2007/10/03)
The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.
New easily accessible chiral indole ligands
Cozzi, Pier Giorgio,Prati, Gian Paolo,Umani-Ronchi, Achille
, p. 403 - 406 (2007/10/03)
An efficient and large-scale synthesis of indoles 3 and 4 bearing in 2-position opitically active substituents has been carried out according to the methodology introduced by Fuerstner.Furthermore, starting from indole-2-carbaldeyde, 6, the corresponding chiral indole Schiff bases 7, 8 and 9 have been synthesized.The cobalt complex, prepared from 9 and cobalt(II) acetate, has been shown to catalyze the reduction of acetophenone with NaBH4 in an e. e. of 22percent.
