528561-04-8

Upstream product

• 86032-53-3 2-[(phenylcarbonyloxy)methyl]-1,3-dithiolane 
• 64904-47-8 2-benzoyloxyacetaldehyde 
• 14631-20-0 4-N-Acetylcytosine 
• 528561-00-4 Benzoic acid (1S,2S)-1-oxo-1λ⁴-[1,3]dithiolan-2-ylmethyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of 1,3-dithiolane nucleoside analogues

We report the ready asymmetric synthesis of nucleoside analogues containing a 1,3-dithiolane ring that mimics the sugar moiety of natural nucleosides. The synthesis is accomplished in three main steps from benzoyloxyethanal 1,3-dithiolane, the key step being its conversion into a chiral monosulfoxide by a modified Sharpless sulfo-oxygenation reaction. The nucleoside analogues were obtained in good overall yields and with excellent enantiomeric excesses. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties

This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: STR1 wherein X is S, S=O, or SO2 ; Y is O, S, S=O, or SO2 ; R1