86032-53-3

Upstream product

• 64904-47-8 2-benzoyloxyacetaldehyde 
• 540-63-6 ethane-1,2-dithiol 

Downstream Products

• 528561-02-6 Benzoic acid (1R,2R)-1-oxo-1λ⁴-[1,3]dithiolan-2-ylmethyl ester 
• 528561-00-4 Benzoic acid (1S,2S)-1-oxo-1λ⁴-[1,3]dithiolan-2-ylmethyl ester 
• 528561-14-0 Benzoic acid (2S,4S)-4-(6-chloro-purin-9-yl)-[1,3]dithiolan-2-ylmethyl ester 
• 528561-12-8 Benzoic acid (2S,4R)-4-(6-chloro-purin-9-yl)-[1,3]dithiolan-2-ylmethyl ester 
• 528561-08-2 Benzoic acid (2R,4S)-4-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]dithiolan-2-ylmethyl ester 
• 528561-06-0 Benzoic acid (2S,4S)-4-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]dithiolan-2-ylmethyl ester 
• 528561-10-6 Benzoic acid (2R,4R)-4-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]dithiolan-2-ylmethyl ester 
• 528561-04-8 trans-2-benzoyloxymethyl-4-(N₄'-acetylcytosin-1'-yl)-1,3-dithiolane 
• 186707-03-9 cis-2-benzoyloxymethyl-3-oxo-1,3-dithiolane 
• 86032-47-5 2-Hydroxymethyl-1,3-dithiolane 

Relevant academic research and scientific papers

Asymmetric synthesis of 1,3-dithiolane nucleoside analogues

We report the ready asymmetric synthesis of nucleoside analogues containing a 1,3-dithiolane ring that mimics the sugar moiety of natural nucleosides. The synthesis is accomplished in three main steps from benzoyloxyethanal 1,3-dithiolane, the key step being its conversion into a chiral monosulfoxide by a modified Sharpless sulfo-oxygenation reaction. The nucleoside analogues were obtained in good overall yields and with excellent enantiomeric excesses. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Short synthesis of 2,4-disubstituted 1,3-oxathiolane and 1,3-dithiolane cytosine nucleosides: Facile introduction of a 4-benzoate group using benzoyl peroxide

Introduction of a benzoate group at position 4 in 2-substituted 1,3- oxathiolane and 1,3-dithiolane using benzoyl peroxide is described. The coupling reaction between 1,3-oxathiolane derivatives 3 and pyrimidine bases in the presence of TMSI produced cis

Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties

This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: STR1 wherein X is S, S=O, or SO2 ; Y is O, S, S=O, or SO2 ; R1

SYNTHESIS AND PROPERTIES OF SOME O--GLYCOLALDEHYDES

O-glycolaldehydes (1a-e; alkyl = Et, Pr, Pri, But, and -CH2-, respectively) have been prepared from the corresponding O-glycolaldehyde dimethyl acetals (2a-e) by acid hydrolysis.In anhydrous 1,4-dioxane in the presence of BF3*(Et2O)2, 1a-c were partially transformed into glycolaldehyde bis(dialkyl dithioacetals), 1d afforded trans-2,6-bis(tert-butylthio)-1,4-dioxane and 3,5-bis(tert-butylthio)-1,4-oxathiane, and 1e did not react.The acetals 2a-e were prepared from the appropriate glycolaldehyde dialkyl dithioacetal by O-alkylation with bromoacetaldehyde dimethyl acetal.