528561-08-2Relevant academic research and scientific papers
Asymmetric synthesis of 1,3-dithiolane nucleoside analogues
Caputo, Romualdo,Guaragna, Annalisa,Palumbo, Giovanni,Pedatella, Silvana
, p. 346 - 350 (2007/10/03)
We report the ready asymmetric synthesis of nucleoside analogues containing a 1,3-dithiolane ring that mimics the sugar moiety of natural nucleosides. The synthesis is accomplished in three main steps from benzoyloxyethanal 1,3-dithiolane, the key step being its conversion into a chiral monosulfoxide by a modified Sharpless sulfo-oxygenation reaction. The nucleoside analogues were obtained in good overall yields and with excellent enantiomeric excesses. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
