528587-79-3

Upstream product

• 109-89-7 diethylamine 
• 528587-71-5 (1S,5R)-2-oxo-1-(4-fluorophenyl)-3-oxabicyclo[3.1.0]hexane 
• 459-22-3 4-fluorophenylacetonitrile 

Downstream Products

• 528588-03-6 (1S,2R)-1-(4-fluorophenyl)-2-[(S)-1-azidopropyl]-N,N-diethylcyclopropanecarboxamide 
• 528587-95-3 (1S,2R)-1-(4-fluorophenyl)-2-[(S)-1-hydroxypropyl]-N,N-diethylcyclopropanecarboxamide 
• 528588-19-4 (1S,4S,5R)-2-oxo-4-ethyl-1-(4-fluorophenyl)-3-oxabicyclo[3.1.0]hexane 
• 942493-75-6 (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-(4-fluorophenyl)cyclopropanecarboxamide 
• 528587-87-3 (1S,2R)-1-(4-fluorophenyl)-2-formyl-N,N-diethylcyclopropanecarboxamide 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters

A series of Milnacipran analogs with variation in the aromatic moiety were prepared in high enantiomeric excess. Structure-activity relationships for two parallel enantiomeric series are described. The (-)-(1R,2S)-naphthyl analog (8h) showed the highest potency in the two series and is a triple reuptake inhibitor of the SERT, NET, and DAT.

Synthesis of derivatives of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) modified at the 1-aromatic moiety as novel NMDA receptor antagonists: The aromatic group is essential for the activity

(1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC, 4a), which is a conformationally restricted analogue of antidepressant milnacipran [(±)-1], is a new class of potent noncompetitive NMDA receptor antagonists. A series of PPD