52867-74-0 Usage
Originator
Zoloperone,ZYF Pharm Chemical
Manufacturing Process
To 20% solution of phosgene in toluene, agitated and cooled to 0°C, are
added over 30 min a solution of 1-p-fluoro-benzoyl-1-hydroxy-3-N-[N'-(2-
methoxyphenyl)]piperazinopropane and triethylamine in anhydrous
chloroform. It is agitated at ambient temperature for 5 h, cooled to 0°C and
the solution saturated with gaseous ammonia. The solution is agitated at
ambient temperature for 3 h, filtered and the filtrate dried under reduced
pressure, 4-ρ-fluorophenyl-5-β-(4-o-methoxyphenylpiperazino)ethyl-4-
oxazolin-2-one, melting point 154°C (by alcohol) was obtained.
Check Digit Verification of cas no
The CAS Registry Mumber 52867-74-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,8,6 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52867-74:
(7*5)+(6*2)+(5*8)+(4*6)+(3*7)+(2*7)+(1*4)=150
150 % 10 = 0
So 52867-74-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H24FN3O3/c1-28-19-5-3-2-4-18(19)26-14-12-25(13-15-26)11-10-20-21(24-22(27)29-20)16-6-8-17(23)9-7-16/h2-9H,10-15H2,1H3,(H,24,27)
52867-74-0Relevant academic research and scientific papers
5-Piperazinylalkyl-2(3H)-oxazolones with Neuroleptic Activity
Cascio, Giuseppe,Manghisi, Elso,Fregnan, Giancarlo
, p. 2241 - 2247 (2007/10/02)
A series of new 4-aryl-5--2(3H)-oxazolones was synthesized and tested for neuroleptic activity in mice and rats.Several compounds exhibited interesting neuroleptic activity with very low liability to the extrapyramidal side
