52873-25-3

Upstream product

• 64-17-5 ethanol 
• 5106-98-9 4-chlorosalicylic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 13659-23-9 2-Bromo-5-chlorophenol 

Downstream Products

• 23958-94-3 Chlor-5-(dihydroxy-2.3-propoxy-2)-benzoesaeureethylester 
• 113800-96-7 2-Butoxy-4-chlorobenzoic acid ethyl ester 
• 112767-60-9 2-Butoxy-4-chlorobenzoic acid 
• 112767-67-6 2-Butoxy-4,5-dichlorobenzoic acid 
• 112767-66-5 2-Butoxy-4-chloro-5-aminobenzoic acid 
• 112767-65-4 Ethyl 2-butoxy-4-chloro-aminobenzoate 
• 112767-68-7 2-Butoxy-4-chloro-5-nitrobenzoic acid chloroanhydride 
• 112767-63-2 2-Butoxy-4-chloro-5-nitrobenzoic acid 
• 112767-64-3 Ethyl 2-butoxy-4-chloro-5-nitrobenzoate 
• 112767-61-0 2-Butoxy-4-chloro-5-sulfamoylsalicylic acid 
• 25082-86-4 Carbamic acid 3-(2-carbamoyl-4-chloro-phenoxy)-2-hydroxy-propyl ester 
• 960063-83-6 C₁₃H₁₅ClO₅ 

Relevant academic research and scientific papers

Synthesis of Phenanthrene Derivatives by Intramolecular Cyclization Utilizing the [1,2]-Phospha-Brook Rearrangement Catalyzed by a Bronsted Base

The synthesis of functionalized phenanthrene derivatives was achieved by intramolecular cyclization utilizing the [1,2]-phospha-Brook rearrangement under Bronsted base catalysis. Treatment of biaryl compounds having an α-ketoester moiety and an alkyne moiety at the 2 and 2′ positions, respectively, with diisopropyl phosphite in the presence of a catalytic amount of phosphazene base P2-tBu provides 9,10-disubstituted phenanthrene derivatives in high yields. This reaction involves the generation of an ester enolate through an umpolung process, that is, addition of diisopropyl phosphite to a keto moiety followed by the [1,2]-phospha-Brook rearrangement, the intramolecular addition to an alkyne, and the [3,3] rearrangement of the allylic phosphate moiety in a consecutive fashion.

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.

Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2 H)-benzofuranone derivatives

A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2 H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2 H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities.