13659-23-9

Usage

Chemical Properties

Pale yellow crystalline powder

InChI:InChI=1/C6H4BrClO/c7-5-2-1-4(8)3-6(5)9/h1-3,9H

Upstream product

• 823-57-4 2-bromo-5-chloroaniline 
• 108-43-0 3-monochlorophenol 
• 1193-72-2 1-bromo-2,4-dichlorobenzene 
• 124-41-4 sodium methylate 
• 16817-43-9 5-Bromo-2-chloroanisole 
• 255051-38-8 4-(4-chloro-2-(R,S)-methylsulfinylphenyl)piperidine 
• 41513-04-6 2-chloro-5-bromonitrobenzene 
• 174913-09-8 2-bromo-5-chloroanisole 

Downstream Products

• 1056942-37-0 1-bromo-4-chloro-2-(difluoromethoxy)benzene 
• 1611444-69-9 1-bromo-2-(2-bromoethoxy)-4-chlorobenzene 
• 1611444-68-8 1-(2-(2-bromo-5-chlorophenoxy)ethyl)-4-methylpiperazine 
• 1567219-26-4 (S)-1-bromo-4-chloro-2-(pent-4-en-2-yloxy)benzene 
• 1377503-12-2 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 898538-44-8 1-bromo-4-chloro-5-(4-ethylbenzyl)-2-methoxybenzene 
• 1036955-11-9 (5-bromo-2-chloro-4-methoxyphenyl)(4-ethylphenyl)methanone 
• 1006590-10-8 (5-bromo-2-chloro-4-methoxyphenyl)(4-ethoxyphenyl)methanone 

Relevant academic research and scientific papers

Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners

The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Regioselective monobromination of substituted phenols in the presence of β-cyclodextrin

Cyclodextrin acts as a restricting nanovessel to enhance regioselectivity in bromination of substituted phenols such as 3-nitrophenol, 2-chlorophenol, 3-chlorophenol, and 4-chlorophenol. In contrast to solution bromination, cyclodextrin facilitates regioselective monobromination and formation of polybrominated products are substantially reduced. Selectivities in brominations are also observed in water and in the solid state. The observed results are rationalized on the basis of specific modes of inclusion of substituted phenols inside the cyclodextrin cavity and find strong support from energy minimization studies and 1H-1H NOESY.

ANTIDIABETIC BICYCLIC COMPOUNDS

Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

SEROTONERGIC BENZOFURANS

The present invention provides serotonergic benzofurans of Formula (I): where A, R, R, R, R, and R are as described in the specification.

N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS

A compound of formula I wherein: R is alkyl; R1 is optionally substituted phenyl 2-oxo-tetrahydro-1(2H)-pyrimidinyl, or 2-oxo-1-piperidinyl; R2 is hydrogen, alkoxy, alkanoyloxy, alkoxycarbonyl, alkanoylamino, acyl, alkyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl where the alkyl groups are the same or different, hydroxy, thioacyl, thiocarbamoyl, N-alkylthiocarbamoyl, or N,N-dialkylthiocarbamoyl where the alkyl groups are the same or different. X1 and X2 are independently hydrogen or halo, provided that at least one of X1 or X2 is halo; and R3, R4, R5 and R6 are independently hydrogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, or alkylsulfonyl are antagonists of at least one tachykinin receptor and are useful in the treatment of depression, anxiety, asthma, pain, inflammation, urinary incontinence and other disease conditions. Process for their preparation are described, as are compositions containing them and their use.

β-methoxy acrylic acid derivatives, method for preparing same, and use of said derivatives as pesticides

A subject of the invention is the products of formula (I): STR1 in which: R1, R2 and R3, identical or different, represent a linear, branched or cyclic alkyl radical, an alkenyl or alkynyl radical, containing up to 8 carbon atoms, optionally substituted by one or more halogen atoms, an aryl radical optionally substituted by one or more halogen atoms, one or more hydroxyl radicals, one or more linear or branched alkyl radicals, optionally substituted by one or more halogen atoms, one or more O-alkyl or S-alkyl radicals optionally substituted by one or more halogen atoms, X represents a hydrogen atom, a halogen atom, an alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl or S-alkynyl radical, optionally substituted by one or more halogen atoms and containing up to 11 carbon atoms, an aryl radical containing up to 14 carbon atoms, a C N, NO2, NH2, STR2 CO2 alk3 radical, alk1, alk2 and alk3, identical to or different from each other, representing an alkyl radical containing up to 8 carbon atoms, R4 represents one of the values indicated above for X with the exception of hydrogen.