18615-59-3 Usage
Uses
Used in Pharmaceutical Industry:
4-CHLORO-8-FLUORO-2-METHYLQUINOLINE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-8-FLUORO-2-METHYLQUINOLINE serves as an intermediate in the production of agrochemicals. Its properties make it suitable for the creation of compounds that can be used in pest control and crop protection.
Used in Organic Compounds Synthesis:
4-CHLORO-8-FLUORO-2-METHYLQUINOLINE is utilized in the synthesis of other organic compounds, contributing to the development of novel chemical entities with diverse applications in research and industry.
Used in Biological Research:
Due to its potential antimicrobial and antitumor properties, 4-CHLORO-8-FLUORO-2-METHYLQUINOLINE is employed in biological research to explore its effects on various microorganisms and its possible role in cancer treatment.
Safety Precautions:
Check Digit Verification of cas no
The CAS Registry Mumber 18615-59-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,1 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18615-59:
(7*1)+(6*8)+(5*6)+(4*1)+(3*5)+(2*5)+(1*9)=123
123 % 10 = 3
So 18615-59-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H7ClFN/c1-6-5-8(11)7-3-2-4-9(12)10(7)13-6/h2-5H,1H3
18615-59-3Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
