528819-01-4

Basic information

• Product Name: N-[(1R)-2,2-dimethyl-1-phenylpropyl]-2,2,2-trifluoroacetamide
• Synonyms: N-[(1R)-2,2-dimethyl-1-phenylpropyl]-2,2,2-trifluoroacetamide
• CAS NO: 528819-01-4
• Molecular Weight: 259.271
• Mol File: 528819-01-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(1R)-2,2-dimethyl-1-phenylpropyl]-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R)-2,2-dimethyl-1-phenylpropyl]-2,2,2-trifluoroacetamide(528819-01-4)
• EPA Substance Registry System: N-[(1R)-2,2-dimethyl-1-phenylpropyl]-2,2,2-trifluoroacetamide(528819-01-4)

Safety Data

• Hazardous Substances Data: 528819-01-4(Hazardous Substances Data)

Upstream product

• 108082-57-1 (1S)-2,2-dimethyl-1-phenylpropan-1-aminium chloride 
• 407-25-0 trifluoroacetic anhydride 
• 528819-08-1 N-[(1E)-2,2-dimethylpropylidene]-[(4R,5R)-4,5-diphenyl-1,3-dioxolan-2-yl]amine 
• 630-19-3 pivalaldehyde 

Downstream Products

• 20859-02-3 L-tert-Leucine 

Relevant articles and documents

Orthoacylimines: A new class of chiral auxiliaries for nucleophilic addition of organolithium reagents to imines

A new class of orthoacylimine-derived chiral auxiliaries has been synthesized and tested in the nucleophilic addition of organolithium reagents to imines. The precursors can be prepared by an aza-Wittig reaction between the corresponding orthoacyl azide and a variety of aldehydes in the presence of trialkylphosphines. The nucleophilic addition of organolithium reagents led to the addition products in good yields and with good to excellent diastereoselectivities (from 85:15 to 99:1). The chiral, nonracemic secondary amines could be readily obtained under mild hydrolytic condition. Furthermore, the chiral auxiliary can be recovered in quantitative yield and reconverted to the starting orthoacyl azide precursor. This method was applied to the synthesis of (S)-t-leucine.