528836-49-9

Upstream product

• 528836-44-4 di-tert-butyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenoxycarbonyl-L-glutamate 
• 7143-01-3 Methanesulfonic anhydride 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 528836-40-0 di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]carbamoyloxymethyl}phenyloxycarbonyl L-glutamate 
• 304015-61-0 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline 
• 304015-62-1 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine 

Downstream Products

• 528836-55-7 di-tert-butyl 4-{[4'-(N,N-bis(2''-iodoethyl)amino)phenyl]carbamoyloxymethyl}phenyloxycarbonyl-L-glutamate 
• 528836-60-4 di-tert-butyl 4-{[4'-(N,N-bis(2''-bromoethyl)amino)phenyl]carbamoyloxymethyl}phenyloxycarbonyl-L-glutamate 

Relevant academic research and scientific papers

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT

Nineteen novel potential self-immolative prodrugs and their corresponding drugs have been synthesized for gene-directed enzyme prodrug therapy (GDEPT) with carboxypeptidase G2 (CPG2) as the activating enzyme. The compounds are derived from o- and p-amino