528836-68-2

Upstream product

• 528836-36-4 4-(N'-benzyloxycarbonyl)amino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline 
• 528836-37-5 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline 
• 304015-61-0 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline 
• 304015-62-1 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-1,4-benzenediamine 
• 528836-47-7 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-hydroxyethyl)aniline 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 528836-53-5 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-mesyloxyethyl)aniline 

Relevant academic research and scientific papers

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT

Nineteen novel potential self-immolative prodrugs and their corresponding drugs have been synthesized for gene-directed enzyme prodrug therapy (GDEPT) with carboxypeptidase G2 (CPG2) as the activating enzyme. The compounds are derived from o- and p-amino